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EC number: 225-862-7 | CAS number: 5124-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Name: FAT 36014/Z
EAS Test item code: 2014-000181
Chemical name: 3-Nitro-n-phenyl-4-(phenylamino)benzene sulfamide
CAS number: 5124-25-4
Density: not applicable
Date of analysis: 07 Aug 2013
Batch number: Q30661AASY
Appearance / colour: powder / yellow
Purity analysed: 94 % w/w
Molecular weight: 369.4 g/mol
Expiry date: 08 Aug 2018
Storage conditions: ambient, dark, dry - Radiolabelling:
- no
- Analytical monitoring:
- not specified
- Details on sampling:
- The test item solutions were prepared by adding 0.5 mL of a 500 mg/L stock solution into an 100 mL volumetric flask and accurately filled up with thebuffer solutions. Under argon atmosphere 2.0 mL of the test item solutions were given into several amber glass vials. The vials were closed with Teflon sealed screw caps. At the sampling time the samples were diluted with 2.0 mL acetonitrile acidified with 1 % phosphoric acid. The concentrationdid not exceed 0.01 M or the half saturation concentration. The determined effective concentrations prior to storage at 50 °C were 2.23 mg/L at pH 4.0, 2.22 mg/L at pH 7.0 and 2.49 mg/L at pH 9.0.
- Buffers:
- The test was carried out at three different pH values: 4.0, 7.0 and 9.0. For this purpose, buffer solutions were prepared using reagent grade chemicals and deionized water. Applicable buffer systems are described in the Appendix of EC method C.7 (92/69/EC), OECD guideline 111. The citrate buffer pH 4.0, the phosphate buffer pH 7.0 and the borate buffer pH 9.0 were prepared in a concentration of 0.05 M on the basis of the undissociated acids. The pH value of the buffer solutions used during the test were determined with a calibrated pH meter at the selected temperature with a precision of 0.1 pH units.
- Estimation method (if used):
- None
- Details on test conditions:
- The test was carried out using a thermostatically controlled water bath at ± 0.5 °C of the chosen temperature. The temperature was kept and measured to within ± 0.1 °C. Photolytic interference was avoided. All suitable precautions were taken to exclude dissolved oxygen (bubbling the buffer with argon for five minutes before preparing the test solution).
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.23 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.22 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.49 mg/L
- Number of replicates:
- 4 at each pH-value
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- None
- Preliminary study:
- A preliminary test was performed at 50 ± 0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours. These values correspond to a half-life time higher than one year under conditions more representative of those of the environment (25 °C).
- Test performance:
- None
- Transformation products:
- not measured
- % Recovery:
- 99.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.5
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 100.4
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- No significant changes of the content in the samples were observed. At pH 4, 7 and 9 less than 10 % of the test item were hydrolysed within 120 hours at 50 °C.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The degradation of FAT 36014/Z was less than 10 % at pH 4, pH 7, pH 9 at 50 °C over a period of 120 hours. Therefore, the corresponding half life time at 25 °C can be estimated to be longer than one year.
- Executive summary:
The abiotic degradation of FAT 36014/Z as a function of pH in aqueous solution was determined according to OECD guideline 111 method C.7 (440/2008). It was shown that the hydrolysis of FAT 36014/Z is negligible within the pH range relevant for natural environments (pH 4 to pH 9). The half-life times at pH 4,7 and 9 are expected to be above one year at 25 °C in each case. Because the test item is stable to hydrolysis no further hydrolysis tests are necessary. The degradation of FAT 36014/Z was less than 10 % at pH 4, pH 7, pH 9 at 50 °C over a period of 120 hours. Therefore, the corresponding half-life time at 25 °C can be estimated to be longer than one year.
Reference
Table1: Time course of FAT 36014/Z concentration at pH 4 at 50 °C
Time |
Determined Content of FAT 36014/Z TE in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
2.23 |
100.0 |
|
120 |
2.21 |
99.1 |
Table2: Time course of FAT 36014/Z concentration at pH 7 at 50 °C
Time |
Determined Content of FAT 36014/Z in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
2.22 |
100.0 |
|
120 |
2.21 |
99.5 |
Table3: Time course of FAT 36014/Z concentration at pH 9 at 50 °C
Time |
Determined Content of FAT 36014/Z in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
2.49 |
100.0 |
|
120 |
2.50 |
100.4 |
Description of key information
A study was performed to measure the abiotic degradation of FAT 36014/Z as a function of pH in aqueous solution according to OECD guideline 111 method C.7 (440/2008). It was shown that the hydrolysis of FAT 36014/Z is negligible within the pH range relevant for natural environments (pH 4 to pH 9). The half-life times at pH 4,7 and 9 are expected to be above one year at 25 °C in each case. Because the test item is stable to hydrolysis no further hydrolysis tests are necessary. The degradation of FAT 36014/Z was less than 10 % at pH 4, pH 7, pH 9 at 50 °C over a period of 120 hours. Therefore, the corresponding half life time at 25 °C can be estimated to be longer than one year.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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