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EC number: 221-590-8 | CAS number: 3153-26-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Compte-tenu de sa solubilité dans l’eau d’environ 9.0 g/L, la substance à enregistrer: acétylacétonate de Vanadyle (substance cible) est un crystal ionique qui se dissocie presque entièrement en espèces chargées (les deux substances sources): les anions organiques d’acétylacétone (aussi appelé 2,4-pentanedione) et les cations métalliques de Vanadium tetravalents (V4+). La méthode d’évaluation des propriétés sensibilisantes pour la peau de de la substance à enregistrer peut donc être basée sur une approche par références croisées (« Read across »), en considérant les propriétés sensibilisantes pour la peau de sa partie organique (2,4-pentanedione) et de la partie inorganique (le Vanadium). Les études existantes indiquent que la 2,4-pentanedione (OECD 2001) ne montrent pas de propriétés sensibilisantes pour la peau alors qu’il n’existe aucune indication que le Vanadium a des propriétés sensibilisantes pour la peau (Costigan et al., 2001). Aucune étude conventionnelle n'existe permettant d'évaluer les propriétés sensibilisante du Vanadium (Costigan, 2001). Cela dit, une étude avec des primates ou une évaluation des propriétés sensibilisantes du Vanadium (réaction dermale immédiate ou différée en combinaison avec une protéine) a
été effectuée s'est avérée négative (Knecht et al., 1992). De ce fait, la substance à enregistrer, l’acétylacétonate de Vanadium, peut être considérée comme non sensibilisant cutané.
Références:
Costigan M, Cary R, Dobson S (2001). Concise International Chemical Assessment Document 29. Vanadium pentoxide and other inorganic Vanadium compounds. World Health Organisation, Geneva, Switzerland
Knecht EA, Moorman WJ, Clark JC, Hull RD, Biagini RE, Lynch DW, Boyle TJ, Simon SD (1992) Pulmonary reactivity to
vanadium pentoxide following subchronic inhalation exposure in a non-human primate animal model. Journal of applied
toxicology, 12:427–434.
OECD Organisation for Economic Co-operation and Development (2001). 2,4-Pentanedione. CAS N°: 123-54-6. SIDS Initial Assessment Report for SIAM 13 (Paris, France, in June) United Nations Environment Programme (UNEP) Publications, Nairobi, Kenya. 82 p.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Jusqu'à 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- 5 cochons d'inde testés
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- Pas applicable
- Specific details on test material used for the study:
- Non disponible
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Non disponible
- Positive control results:
- Non disponible
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- Non disponible
- No. with + reactions:
- 1
- Total no. in group:
- 5
- Clinical observations:
- Réaction faible observée chez 1 animal
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: Résultats ambigus ne permettant pas une classification claire de la 2,4 pentanedione concernant la sensibilisation de la peau.
- Conclusions:
- Les résultats de cette étude ne permettent pas une classification claire de la 2,4 pentanedione concernant la sensibilisation de la peau.
- Executive summary:
Dans cette étude, 5 cochons d'inde ont été soumis à un test de sensibilisation de la peau standard.
1 cochon d'inde sur 5 a montré une réponse faible tandis que les 4 animaux restants sont restés normaux
Le résultat global de l'étude a été jugé ambigu par les auteurs de l'étude pour permettre une classification
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Jusqu'à 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Human patch Study
- GLP compliance:
- not specified
- Type of study:
- not specified
- Specific details on test material used for the study:
- Non disponible
- Species:
- other: Test conduits sur des humains
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Non disponible
- Positive control results:
- Non disponible
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- Non communiqé
- No. with + reactions:
- 2
- Total no. in group:
- 12
- Clinical observations:
- Aucune
- Remarks on result:
- other: Après 24h d'exposition, 3 individus ne montraient aucun signe de réaction alors que 7 autres ont montré une réaction douteuse (non confirmée)
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- Non communiqué
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Clinical observations:
- Aucune
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- Non communiqué
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Clinical observations:
- Aucune
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- La partie organique de la substance à enregistrer (2,4-pentanedione) n'apparait pas avoir de propriétés sensibilisantes pour la peau même si une légère irritation est notée.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Sur la base de l'évaluation susmentionnée des propriétés sensibilisante pour la peau de l’acétylacétonate de Vanadyle, la substance à enregistrer doit être considérée comme non sensibilisante pour la peau conformément au CLP (règlement (CE) n ° 1272/2008 du Parlement européen et du Conseil) en tant que mise en œuvre du système UN-GHS dans l'Union Européenne.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.