Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-359-1 | CAS number: 3077-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Only limited data is available for the environmental fate of the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1). Therefore, read-across was performed to the structurally and chemically closely related source substance2-[(2-hydroxyethyl)(4-methylphenyl)amino]ethan-1-ol(EC 911-490-9) in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VIII of the Regulation.
The source substance is a multi-constituent, which is predominantly composed of the target substance (2,2’-[4-methylphenyl)imino] diethanol, CAS 3077-12-1) itself as well as a second component named (2-{[(2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino)ethanol, CAS 878391-30-1). The second component only differs in the composition of one side chain, which additionally contains two C-atoms and an ether group. Based on the high degree of structural and chemical similarity and the fact that the source substance principally consists of the target molecule, the target substance is expected to exhibit a similar environmental fate profile as the selected source substance. The structural differences of the second constituent of the source substance are not expected to significantly affect the overall environmental fate profile. Therefore, the source substance is considered a suitable representative for the prediction of the environmental fate and pathways of the target substance by extrapolation from source data, in accordance with Annex XI, item 1.5, of Regulation (EC) No 1907/2006. A detailed read-across approach justification is provided in IUCLID section 13.
The target substance is a mono-constituent substance characterized by high water solubility (19.8 g/L 20 °C, pH 6.91, OECD 105), low vapour pressure (0.000447 Pa at 25°C, MPBWIN v1.43), and a low partition coefficient (2.0 at 35 °C and neutral pH, OECD 117, HPLC method). The adsorption potential (log Koc) is also expected to be low, since it is related to the octanol water partition coefficient, which is supported by the low log Koc value reported for the source substance (2.22 – 2.44). Based on these physico-chemical properties, the substance is expected to preferentially distribute into the water compartment if released to the environment and could moderately also distribute into the soil and sediment compartment. Furthermore, the substance is not rapidly biodegradable by microorganisms of activated sludge (1.5% in 28 d, CO2 evolution, OECD 301 B).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.