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EC number: 218-658-4 | CAS number: 2212-32-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In vivo studies of skin irritation/corrosion and eye irritation are available for the submission substances. Waivers are provided for in vitro studies of skin irritation/corrosion and eye irritation due to the availability of in vivo data.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions- incomplete characterization of the test substance (no data on test substance purity available)- no GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- Test material is N, N, N' Trimethylaminoethyl-Ethanolamin
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Gaukler; D - 6050 Offenbach/Main, FRG
Weight at study initiation: 3.42 kg (male), 2.98 (females)
Housing: individually in stainless steel cages with wire mesh floors
Diet: Kliba 341, 4 mm, Klingentalmuehle AG, CH 4303, Kaiseraugst, Switzerland; available ad libitum
Water: about 250 mL tap water per animal per day; available ad libitum
Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
Temperature (°C): 20 - 24
Humidity (%): 30 -70
Photoperiod: 12 hours light/dark cycle - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal served as control
- Amount / concentration applied:
- TEST MATERIAL
Amount(s) applied: 0.5 mL applied on a 2.5 x 2.5 cm test patch
Concentration: undiluted - Duration of treatment / exposure:
- 3 minutes and 1 hour and 4 hours
- Observation period:
- 15 days for animals treated treated for 3 minutes and 1 hour.. Readings were performed 4, 24, 48, 72 hours, 8 and 15 days after beginning of application.
8 days for animals treated for 4 hours. Readings were performed 4, 24, 48, 72 hours, 8 days after beginning of application. - Number of animals:
- 3 animals per incubation duration
- Details on study design:
- TEST SITE- Shavings: performed at least 15 hours before treatment
Site of exposure: upper third of the back or flanks
Area of exposure: coverage: 2.5 cm x 2.5 cm
Type of wrap if used: test patches were secured in position with a porous dressing (four layers of absorbent gauze + porous bandage)
REMOVAL OF TEST SUBSTANCE
Washing: yes (with lutrol and lutrol/water (1:1))
Time after start of exposure: 3 minutes and 1 hour
SCORING SYSTEM: Draize method (see below) - Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Scaling observed at 8 days.
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Scaling observed at 8 days.
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Score after 4/24/48/72 hours and 8 days = 2/2/1/0/0
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration of 4 hours)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 1 hour)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 1 hour)
- Basis:
- animal: # 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration of 1 hour)
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration of 3 minutes)
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration of 3 minutes)
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Other effects:
- Following the 4-hour exposure, necrosis was noted in one animal at 48 and 72 hours. At 8 days this was noted as superficial necrosis by gross pathological examinaition. Haemorrhage was noted in the same animal at 4 hour and 24 hours following exposure. Scaling was observed in the remaining two animals following the 4-hour exposure.
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- For the animals exposed for 4 hours, the mean erythema score (24/48/72 hours) was 2.3 and the mean oedema score was 0.89 (24/48/72 hours). Since necrosis was noted at 48 and 72 hours in one animal exposed for 4 hours and the study was terminated on Day 8 thereby the observation period was less than 21 days this did not allow for assessment of reversibility of the damage. The test material is considered to be corrosive to skin (category 1C) under CLP.
- Executive summary:
An in vivo skin irriation study was conducted in accordance with OECD 404 with test material N, N, N' trimethylaminoethyl-Ethanolamin. The test sites (2.5 cm x 2.5 cm) of Vienna white rabbits were shaved at least 15 hours prior to the addition of 0.5 mL of the test material with semi-occlusive coverage. Three animals were treated for each of three induction times (3 minutes, 1 hour and 4 hours). Following 3 minute exposure, no erythema or oedema was observed in any of the animals at 24, 48 or 72 hour observations. Following 1 hour exposure, erythema was observed in one animal only (mean of 2.7 at 24/48/72 hour) which was reversible within 15 days; no erythema was noted in the remaining two animals. Oedema was not observed for any animals following 1 hour exposure. Following 4 hour exposure, very slight to severe or very severe erythema and none to well defined oedema was obsvered for all animals. This was reversible in two animals within 72 hours, but was irreversible in one animal for at least 8 days (the end of the observation period). Necrosis was noted in the latter animal at 48 and 72 hours. Gross histopathological examination at 8 days confirmed this was superficial necrosis, but since no further information was presented in the report and the study was terminated early this prevented assessment of the reversibility of the damage within 21 days. On the basis of the necrosis, the test material is considered to be corrosive to the skin (Category 1C).
Reference
Observations following 3 minute exposure:
Animal number |
Observation |
|||||||||||
4 hours |
24 hours |
48 hours |
72 hours |
8 days |
15 days |
|||||||
E |
O |
E |
O |
E |
O |
E |
O |
E |
O |
E |
O |
|
Animal 1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Animal 2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Animal 3 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
E Erythema
O Oedema
Observations following 1 hour exposure:
Animal number |
Observation |
|||||||||||
4 hours |
24 hours |
48 hours |
72 hours |
8 days |
15 days |
|||||||
E |
O |
E |
O |
E |
O |
E |
O |
E |
O |
E |
O |
|
Animal 1 |
1 |
0 |
2 |
0 |
3 |
0 |
3 |
0 |
3 |
0 |
0 |
0 |
Animal 2 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Animal 3 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
E Erythema
O Oedema
Observations following 4 hour exposure:
Animal number |
Observation |
|||||||||
4 hours |
24 hours |
48 hours |
72 hours |
8 days |
||||||
E |
O |
E |
O |
E |
O |
E |
O |
E |
O |
|
Animal 1 |
1 |
0 |
2e |
1a |
2e |
0 |
2e |
0 |
0f |
0 |
Animal 2 |
1e |
2a |
2e |
2a |
2e |
1a |
1e |
0 |
0f |
0 |
Animal 3 |
2e |
1a, b |
2e |
2a, b |
4c |
1a |
4c |
1a |
4d, g |
1a |
E Erythema
O Oedema
a Oedema
extending beyond area of exposure
b Haemorrhage
c Necrosis
d Superficial
necrosis
e Erythema
extending beyond area of exposure
f Scaling
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions- incomplete characterization of the test substance (no data on test substance purity available)- no GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- N, N, N Trimethylaminoethyl-Ethanolamin
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
Source: Gaukler; D - 6050 Offenbach/Main, FRG
Weight at study initiation: 2.46 kg (male), 2.88 (female)
Housing: individually in stainless steel cages with wire mesh walk floors
Diet: Kliba 341, 4 mm, Klingentalmuehle AG, CH 4303, Kaiseraugst, Switzerland; available ad libitum (ca. 130 g per day per animal)
Water: about 250 mL tap water per animal per day; available ad libitum
Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
Temperature (°C): 20 - 24
Humidity (%): 30 -70
Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: left eye (untreated)
- Amount / concentration applied:
- Amount applied: 0.1 mL applied in to the conjuctival sac of the right eye.
- Duration of treatment / exposure:
- Eyes were not washed after application.
- Observation period (in vivo):
- 15 days- Reading were performed 1, 24, 48, 72 hours, 8 and 15 days after application.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing (if done): no
SCORING SYSTEM: Draize method - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 8 and 15 days
- Score:
- >= 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 8 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 8 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Remarks:
- 72 hour assessment could not be made
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 48 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 15 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 15 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 15 days
- Remarks on result:
- no indication of irritation
- Other effects:
- See table 2: Table of symptoms
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Conclusions:
- For the animals exposed for 4 hours, the mean corneal score (24/48/72 hours) was 1.6, the mean conjunctivae score was 0.89 (24/48/72 hours) and the the mean chemosis score was 1.7 (24/48/72 hours). The mean iris score was 0.7 based on 2 animals (24/48/72 hours) and a score of 1 was assigned at both 24 and 48 hours for the third animal. Based on the corneal opacity score of 4 for one animal at 8 and 15 days and the irreversible damage, the test material is considered to cause serious eye damage (Category 1) according to CLP
- Executive summary:
An in vivo eye irriation study was conducted in accordance with OECD 405 with test material N, N, N' Trimethylaminoethyl-Ethanolamin. The eyes of three Vienna white rabbits were instillated with 0.1 mL of test material. The test material was not removed. Observations were made 1, 24, 48 and 72 hours and 8 and 15 days after application. The material showed a mean value of 1.6 (24/48/72 hours) for corneal opacity, 2.0 (24/48/72 hours) for conjunctivae and 1.7 (24/48/72 hours) for chemosis. Due to the extent of corneal damage, iritis readings for 1 animal could not be made at 72 hours, however the mean for the remaining two animals was 0.7 (24/48/72 hours) with readings for the former animal were 1 at 24 and 48 hours. With the exception of chemosis which was reversible within at least 15 days, the damage was irreversible. The severity of cornea opacity increased for all three animals between 72 hours and 8 days and worsened or remained the same by 15 days; the opacity score for one rabbit was 4 at 8 and 15 days after installation. On the basis of the corneal opacity and the irreversible damage, the test material is considered to cause serious eye damage (Category 1).
Reference
Observations
Parameter |
Observation period |
Animal 1 |
Animal 2 |
Animal 3 |
Cornea |
1 hour |
1 |
1 |
1 |
24 hours |
1 |
1 |
2 |
|
48 hours |
1 |
1 |
2 |
|
72 hours |
1 |
2 |
3 |
|
8 days |
2 |
3 |
4 |
|
15 days |
2 |
2 |
4 |
|
Iris |
1 hour |
0 |
0 |
0 |
24 hours |
0 |
1 |
1 |
|
48 hours |
0 |
1 |
1 |
|
72 hours |
1 |
1 |
a |
|
8 days |
1 |
1 |
a |
|
15 days |
b |
b |
a |
|
Conjunctivae |
1 hour |
2 |
2 |
2 |
24 hours |
2 |
2 |
2 |
|
48 hours |
2 |
2 |
2 |
|
72 hours |
2 |
2 |
2 |
|
8 days |
2 |
2 |
2 |
|
15 days |
1 |
2 |
1 |
|
Chemosis |
1 hour |
2 |
2 |
2 |
24 hours |
1 |
2 |
2 |
|
48 hours |
1 |
2 |
2 |
|
72 hours |
1 |
2 |
2 |
|
8 days |
0 |
1 |
1 |
|
15 days |
0 |
0 |
0 |
a reading cannot be made due to severe corneal opacity
b reading cannot be made due to marginal vascularisation of the cornea
Table of symptoms
|
Animal 1 |
Animal 2 |
Animal 3 |
Discharge of blood |
≥ 24 h – 48 h |
≥ 1 h – 72 h |
≥ 1 h – 72 h |
Loss of corneal tissue |
- |
≥ 72 h – 8 d |
≥ 1 h – 8 d |
Loss of hair at margins of eyelids |
- |
≥ 8 – 15 d |
≥ 8 – 15 d |
Marginal vascularisation of the cornea |
15 d |
≥ 8 – 15 d |
≥ 8 – 15 d |
Pupil contracted |
≥ 1 h – 8 d |
≥ 1 h – 8 d |
≥ 1 h – 48 h |
Pannus |
15 d |
- |
- |
Small retractions in the eyelid |
15 d |
≥ 24 h – 15 d |
≥ 72 h – 15 d |
Suppuration |
72 h |
≥ 48 h – 15 d |
≥ 48 h – 15 d |
Staphyloma |
- |
15 d |
15 d |
After 15 days, the study was discontinued because of serious irritation effects on the eyes.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
An in vivo skin irriation study was conducted in accordance with OECD 404 with test material N, N, N' trimethylaminoethyl-Ethanolamin. The test sites (2.5 cm x 2.5 cm) of Vienna white rabbits were shaved at least 15 hours prior to the addition of 0.5 mL of the test material with semi-occlusive coverage. Three animals were treated for each of three induction times (3 minutes, 1 hour and 4 hours). Following 3 minute exposure, no erythema or oedema was observed in any of the animals at 24, 48 or 72 hour observations. Following 1 hour exposure, erythema was observed in one animal only (mean of 2.7 at 24/48/72 hour) which was reversible within 15 days; no erythema was noted in the remaining two animals. Oedema was not observed for any animals following 1 hour exposure. Following 4 hour exposure, very slight to severe or very severe erythema and none to well defined oedema was obsvered for all animals. This was reversible in two animals within 72 hours, but was irreversible in one animal for at least 8 days (the end of the observation period). Necrosis was noted in the latter animal at 48 and 72 hours. Gross histopathological examination at 8 days confirmed this was superficial necrosis, but since no further information was presented in the report and the study was terminated early this prevented assessment of the reversibility of the damage within 21 days. On the basis of the necrosis, the test material is considered to be corrosive to the skin (Category 1C).
Eye irritation
An in vivo eye irriation study was conducted in accordance with OECD 405 with test material N, N, N' Trimethylaminoethyl-Ethanolamin. The eyes of three Vienna white rabbits were instillated with 0.1 mL of test material. The test material was not removed. Observations were made 1, 24, 48 and 72 hours and 8 and 15 days after application. The material showed a mean value of 1.6 (24/48/72 hours) for corneal opacity, 2.0 (24/48/72 hours) for conjunctivae and 1.7 (24/48/72 hours) for chemosis. Due to the extent of corneal damage, iritis readings for 1 animal could not be made at 72 hours, however the mean for the remaining two animals was 0.7 (24/48/72 hours) with readings for the former animal were 1 at 24 and 48 hours. With the exception of chemosis which was reversible within at least 15 days, the damage was irreversible. The severity of cornea opacity increased for all three animals between 72 hours and 8 days and worsened or remained the same by 15 days; the opacity score for one rabbit was 4 at 8 and 15 days after installation. On the basis of the corneal opacity and the irreversible damage, the test material is considered to cause serious eye damage (Category 1).
Justification for classification or non-classification
N, N, N' trimethylaminoethyl-Ethanolamne is classified as skin corrosive (category 1C) based on the irreversible nature of the skin damage in two/three animals and the absence of further histopathological details that the necrosis was superficial.
N, N, N' trimethylaminoethyl-Ethanolamne is classified as causes serious eye damage (category 1) based on the irreversible nature of the eye damage and the extent of corneal opacity in one animal at 8 and 15 days following installation.
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