Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-021-9 | CAS number: 505-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2010-05-20 to 2010-06-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- Adopted 17 July 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- The inoculum contained a mixed population of microorganisms obtained from the secondary effluent of wastewater treatment plant of Pardubice processing predominantly municipal sewage. The fresh collected wastewater was filtered through paper filter. COD was determined and wastewater was aerated till using. The inoculum preparation is in conformity with the recommendations of the test guidelines.
The volume of wastewater for the inoculation of mineral medium was 2.0 ml per 1 L of medium. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 3.35 mg/L
- Based on:
- COD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The test substance in mineral medium is inoculated with a relatively small number of microorganisms from a mixed population and kept in completely full closed bottles in the dark at constant temperature (2 x 9 bottles).
The following determinations were done simultaneously under the same conditions:
- check of inoculum activity with the reference substance (2 x 9 bottles)
- toxicity test with test and reference substance mixture and inoculated medium (2 x 5 bottles)
- determination of blank (inoculated mineral medium) (2 x 9 bottles)
The bottles were placed into thermostat (20 +/- 1 °C).
Degradation is determined by analysis of dissolved oxygen over a 28-day period.
The zero-time bottles were analysed immediately for dissolved oxygen by the Winkler method.
At the 3rd, 7th, 10th, 14th, 17th, 21st, 24th and 28th day of test, the appropriate bottles from each series were taken off and they were analysed for dissolved oxygen.
Mineral medium was prepared as recommended in the OECD TG 301 D. - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- No preliminary study was performed.
- Test performance:
- There were no deviations from study plan or guidelines during the study.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 14.3
- Sampling time:
- 28 d
- Details on results:
- The oxygen consumption and percentage of the biodegradation of test substance for each test interval and each bottle were calculated (Tables 1 to 4).
The following test validity criteria were fulfilled: (1) Oxygen depletion in the inoculum blank did not exceed 1.5 mg/L after 28 days, (2) The residual concentration of oxygen in the test did not fall below 0.5 mg/L in any time, (3) The difference of extremes of replicate values of the removal of test substance at the end of the test was less than 20%, (4) The percentage degradation of the reference substance reached the level for ready biodegradability by 14 days, (5) In the toxicity test, containing both the test substance and the reference chemical, more than 25% degradation occured in 14 days. The test substance was therefore not inhibitory the inoculum. - Results with reference substance:
- Degradation of 76.3% of reference substance was attained at the end of the study (Table3)
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- In this 28-day study of ready biodegradability, the degradation of 14.3% of the test substance propylal was attained in the end of the study.
- Executive summary:
The test substance, propylal, was tested for the ready biological degradability in Closed Bottle test.
The test was performed according to: Method C.4E – Closed Bottle Test, Council Regulation (EC) No 440/2008, published in O.J.L 142, 2008.
The results of biological degradation are related to experimentally determined COD values of test and reference substance at the beginning of the test.
The test substance had sufficient solubility in used mineral medium. The dosage from the stock solution was carried out.
Sodium benzoate was used as the reference substance. The dosage was carried out from the stock solution.
COD of the test substance in medium at the beginning of the main test: 3.35 mg/L.
COD of reference substance in medium at the beginning of the main test: 3.44 mg/L.
In parallel to the main test the toxicity test was performed.
As the test substance has not any contents of nitrogen in the chemical composition, oxidized nitrogen forms were not determined and the correction for nitrification was not carried out.
The test was performed at temperature of 20 ± 1°C with the pH values of solutions 7-8 at the beginning of the test.
The prescribed validity criteria in the test were fulfilled. The test substance was not inhibiting for the used inoculum. Since all criteria of acceptability were met, this study is considered to be valid.
In this 28-day study of ready biological degradability, the degradation of 14.3% of the test substance, propylal, was attained in the end of study.
Reference
Table 1 – Determination of dissolved oxygen concentration in the main test
Concentration |
|
Dissolved oxygen (mg/L) after period (days) |
||||||||
0 |
3 |
7 |
10 |
14 |
17 |
21 |
24 |
28 |
||
Test substance Cz |
Serie 1 |
8.56 |
8.50 |
8.41 |
8.00 |
7.97 |
7.97 |
7.82 |
7.69 |
7.68 |
Serie 2 |
8.56 |
8.50 |
8.41 |
7.98 |
7.95 |
7.97 |
7.82 |
7.72 |
7.68 |
|
Average |
8.56 |
8.50 |
8.41 |
7.99 |
7.96 |
7.97 |
7.82 |
7.71 |
7.68 |
|
Reference substance Cr |
Serie 1 |
8.46 |
6.41 |
6.32 |
6.01 |
5.75 |
5.60 |
5.61 |
5.47 |
5.42 |
Serie 2 |
8.46 |
6.41 |
6.32 |
6.01 |
5.75 |
5.62 |
5.58 |
5.47 |
5.45 |
|
Average |
8.46 |
6.41 |
6.32 |
6.01 |
5.75 |
5.61 |
5.60 |
5.47 |
5.44 |
|
Blank experiment C0 |
Serie 1 |
8.48 |
8.54 |
8.53 |
8.34 |
8.33 |
8.23 |
8.11 |
8.05 |
8.07 |
Serie 2 |
8.46 |
8.51 |
8.50 |
8.34 |
8.33 |
8.23 |
8.11 |
8.05 |
8.07 |
|
Average |
8.47 |
8.53 |
8.52 |
8.34 |
8.33 |
8.23 |
8.11 |
8.05 |
8.07 |
Table 2 - Determination of dissolved oxygen concentration in the toxicity test
Concentration |
|
Dissolved oxygen (mg/L) after period (days) |
||||
0 |
3 |
7 |
10 |
14 |
||
Test + reference substance C (z+r) |
Serie 1 |
8.54 |
6.45 |
6.26 |
5.92 |
5.81 |
Serie 2 |
8.52 |
6.45 |
6.26 |
5.90 |
5.81 |
|
Average |
8.53 |
6.45 |
6.26 |
5.91 |
5.81 |
|
Blank experiment C0 |
Serie 1 |
8.48 |
8.54 |
8.53 |
8.34 |
8.33 |
Serie 2 |
8.46 |
8.51 |
8.50 |
8.34 |
8.33 |
|
Average |
8.47 |
8.53 |
8.52 |
8.34 |
8.33 |
Table 3 – Biodegradation of test and reference substance in the main test
Concentration |
|
Biodegradation (%) after period (days) |
||||||||
0 |
3 |
7 |
10 |
14 |
17 |
21 |
24 |
28 |
||
Test substance (Dt) |
Serie 1 |
0 |
3.4 |
5.8 |
12.8 |
13.4 |
10.4 |
11.3 |
13.4 |
14.3 |
Serie 2 |
0 |
3.4 |
5.8 |
13.4 |
14.0 |
10.4 |
11.3 |
12.5 |
14.3 |
|
Average |
0 |
3.4 |
5.8 |
13.1 |
13.7 |
10.4 |
11.3 |
13.0 |
14.3 |
|
Reference substance (Dt) |
Serie 1 |
0 |
61.2 |
63.5 |
67.4 |
74.7 |
76.2 |
72.4 |
74.7 |
76.7 |
Serie 2 |
0 |
61.2 |
63.5 |
67.4 |
74.7 |
75.6 |
73.3 |
74.7 |
75.9 |
|
Average |
0 |
61.2 |
63.5 |
67.4 |
74.7 |
75.9 |
72.8 |
74.7 |
76.3 |
For the test substance, the following formula was used to calculate the biodegradation percentage: Dt = ((Cz0 – Cz1)-(C00-C01)-Cn1) x 100 / CODz0
For the reference substance, the following formula was used to calculate the biodegradation percentage: Dt = ((Cr0 – Cr1)-(C00-C01)) x 100 / CODr0
Table 4 - Biodegradation of test and reference substance in the toxicity test
Concentration |
|
Biodegradation (%) after period (days) |
||||
0 |
3 |
7 |
10 |
14 |
||
Test + reference substance (Dt) |
Serie 1 |
0 |
31.6 |
34.2 |
36.7 |
38.1 |
Serie 2 |
0 |
31.3 |
33.9 |
36.7 |
37.8 |
|
Average |
0 |
31.4 |
34.1 |
36.7 |
38.0 |
For the test + reference substance, the following formula was used to calculate the biodegradation percentage: Dt = ((C(z+r)0 - C(z+r)1)+(C00-C01)) x 100 / COD (z+r)0
Description of key information
In a 28-day closed bottle test performed according to OECD TG 301D, degradation of 14.3% of Dipropoxymethane was attained at the end of the study.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.