Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-026-8 | CAS number: 131-53-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
pH
Administrative data
- Endpoint:
- pH
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP conditions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2007-10-15
- Specific details on test material used for the study:
- Name: 2,2’ -Dihydroxy-4-methoxybenzophenone
Batch/Lot Number: 8010111
Description:Yellow powder
Expiry Date: 26 August 2008
Storage Conditions: Room Temperature in the dark - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Limited, Bicester, Oxon, UK
- Age at study initiation: 12-20 weeks old
- Weight at study initiation: 2.0-3.5 kg
- Housing: individually housed in suspended cages; the animals were provided with environmental enrichment items
- Diet: free access, 2030 Teklad Global Rabbit diet supplied by Harlan Teklad)
- Water: free access
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23 °C
- Humidity (%): 30-70%
- Air changes (per hr): at least 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12/12h - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5g
VEHICLE
- Amount(s) applied: 0.5 ml - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Type of wrap: elasticated corset
REMOVAL OF TEST SUBSTANCE
- Washing: removed by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: 4h
OBSERVATION TIME POINTS
1h, 24h, 48h and 72h
SCORING SYSTEM:
- Method of calculation: Draize JH 1959 - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- No evidence of skin irritation was noted during the study.
- Other effects:
- All animals showed expected gain in bodyweight during the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material produced a primary irritation index of 0.0 and was classified as Non-irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
- Executive summary:
2,2 -Dihydroxy-4 -methoxybenzophenone was tested according to OECD Test guideline 404 and GLP criterias for its skin irritation potential.
For all three animals, irritation scores were of 0. The test substance is not irritating to the skin of rabbits.
Skin reaction |
Observation time |
Individual scores – rabbit number and sex |
Total |
||
Animal 1 Male |
Animal 2 Male |
Animal 3 Male |
|||
Erythema/Eschar Formation |
1 Hour 24 Hours 48 Hours 72 Hours |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
(0) 0 (0) 0 |
Oedema Formation |
1 Hour 24 Hours 48 Hours 72 Hours |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
(0) 0 (0) 0 |
Sum of 24 and 72-hour readings: 0 |
|||||
Primary irritation index (S/6): 0/6 = 0.0 |
|||||
Classification: NON IRRITANT |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- pH measurement performed before skin irritaiton assessment of the test substance.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2007-10-15
Test material
- Reference substance name:
- Dioxybenzone
- EC Number:
- 205-026-8
- EC Name:
- Dioxybenzone
- Cas Number:
- 131-53-3
- Molecular formula:
- C14H12O4
- IUPAC Name:
- 2-(2-hydroxybenzoyl)-5-methoxyphenol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Name: 2,2’ -Dihydroxy-4-methoxybenzophenone
Batch/Lot Number: 8010111
Description:Yellow powder
Expiry Date: 26 August 2008
Storage Conditions: Room Temperature in the dark
Reagents
- Reagent:
- water
Results and discussion
pH value
- pH value:
- 8.1
- Concentration:
- 10 other: % w/w
Any other information on results incl. tables
10 % w/w aqueous prepration of the test material: pH measured was 8.1 immediately and after 10 minutes.
Applicant's summary and conclusion
- Conclusions:
- The test item has a pH of 8.1 when prepared to a 10% w/w aqueous solution.
- Executive summary:
2,2'-Dihydroxy-4 -methoxybenzophenone has a pH of 8.1 when prepared to a 10% w/w aqueous solution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.