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Diss Factsheets
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EC number: 201-842-3 | CAS number: 88-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity of this substance is the range of oral LD50 value 130-800 mg/kg in rats and mice. Toxic signs were found at 800 mg/kg in males and 130 mg/kg or more in female rats. These were hypoactivity, a prone or lateral position and soiled fur. Bradypnea and Cheyne-Strokes' respiration in moribund animals of both sexes and hypothermia, clonic convulsion, ataxic gait and vocalisation in females were observed.
Studies for acute inhalative and acute dermal toxicity are not available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 130 mg/kg bw
Additional information
The acute oral LD50 value is in the range of 130 -800 mg/kg bw (M: 320 -800 mg/kg, F:130 -320 mg/kg)
number of dead animals/number of dosed animals:
M: 130 mg/kg: 0/5, 320 mg/kg: 0/5; 800 mg/kg; 4/5, 2000 mg/kg: 3/5
F: 130 mg/kg: 0/5, 320 mg/kg: 3/5; 800 mg/kg; 4/5, 2000 mg/kg: 4/5
Studies for acute inhalative and acute dermal toxicity are not available and not necessary, because 6-tert-butyl-m-cresol shall be registrated according REACH Article 18 (transported isolated intermediate).
Additional 6-tert-butyl-m-cresol is classifed as C, R34 (corrosive, causes burns). Studies for acute inhalation and acute dermal toxicity are therefore not justified scientifcally and are precluded on grounds of animal welfare.
Justification for classification or non-classification
from the results of the acute toxicity study the dead rate shows the same tendency in male and female rats - with the exception of the dose group of 320 mg/kg. In this dose group none of the male animals died but 3 of 5 female rats died. In higher dose groups (800 mg/kg) the same number of male and female rats died. In the dose group of 2000 mg/kg 3 of 5 male rats died and 4 of 5 female rats died.
Because the death rate in male and female rats is not very different in each gender with the exception of the dose group of 320 mg/kg where considerable more female rats died - there in no clear evidence for a clear higher sensitivity of the female rats.
In conclusion the LD50 value for both genders seems between 130 and 800 mg/kg bw and not at the lower end of this range.
A classification as Xn (harmful), R22 (harmful if swallowned) is justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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