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Diss Factsheets
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EC number: 201-622-7 | CAS number: 85-68-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity tests with butyl benzyl phthalate in rats and mice (oral, up to 20 g/kg bw), rabbits (dermal, up to 10 g/kg bw), and rats (inhalation, saturated vapour) indicate that this compound does not need to be classified for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 330 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
Additional information
In a reliable study, butyl benzyl phthalate was assessed for acute oral toxicity in male and female F344/N rats and B6C3F1 mice (NTP, 1982). Groups of five rats and five mice of each sex were dosed with up to 20 g/kg bw by oral gavage, and surviving animals were observed for 14 days. Deaths occurred in rats at 2.5 g/kg bw and above and in mice at 5 g/kg bw and above. The LD50 value was estimated to be 2.33 g/kg bw for rats (of both sexes), 6.16 g/kg bw for male mice and 4.17 g/kg bw for female mice. These figures indicate that butyl benzyl phthalate is of low acute oral toxicity to rats and mice. This is supported by another rat study for which few details are available (hence it has been assigned reliability code 4), with an acute oral LD50 value of 20.4 g/kg bw (Birch, 1976a).
When neat Santicizer 160 (butyl benzyl phthalate) was applied to the skin of four New Zealand white rabbits at doses of around 4, 6 and 10 g/kg bw for an exposure period of 24 hours, there were no deaths in the subsequent 2 -week observation period, although the animals showed reductions in appetite and activity. [It is not clear which doses had these effects.] The viscera appeared normal on gross necropsy. The investigators concluded that the LD50 was greater than 10 g/kg bw (Birch, 1976b). Although details are only available in a brief summary report (hence it has been assigned reliability code 4), the data are considered adequate for assessment.
When four male rats were exposed for 6 hours to a saturated atmosphere containing Santicizer 160 (benzyl butyl phthalate) and observed for 3 days, there were no deaths and only mild transient effects, including irregular breathing, moderate lethargy and mild nasal irritation. There is no information provided on the actual test concentration (Younger, 1955).
Justification for classification or non-classification
Acute oral, dermal and inhalation toxicity studies on butyl benzyl phthalate are considered adequate for concluding that the compound does not need to be classified for acute toxicity, under the EU CLP Regulations.
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