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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study conducted in accordance with internationally recognised test methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vanadyl pyrophosphate
- EC Number:
- 406-260-5
- EC Name:
- Vanadyl pyrophosphate
- Cas Number:
- 58834-75-6
- Molecular formula:
- V2P2O9
- IUPAC Name:
- divanadium(4+) (phosphonatooxy)phosphonate dioxidandiide
- Details on test material:
- - Name of test material (as cited in study report): BTN/A
- Chemical name: Vanadyl pyrophosphate
- Chemical formula: (VO)2P207
- Relative molar mass: 307.8
- Physical state Fine, dark-brown powder
- Lot/batch No.:0003
- Purity: Vanadium - 30.1%, phosphorous 21.0% by weight
- Storage condition of test material: Cool, dry, well ventilated room
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK), Kent, England
- Age at study initiation: circa 5 weeks
- Weight at study initiation: Males: 104 - 145 g; females: 104 - 134 g
- Fasting period before study: circa 18 hours
- Housing: 5 animals/cage in stainless steel cages with grid floor
- Diet (e.g. ad libitum): Pelleted rodent diet, Biosure, Cambridge, Englan, ad libitum except for overnight pre-dose fast
- Water (e.g. ad libitum): Municipal tap water, ad libitum
- Acclimation period: At least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 25 deg C
- Humidity (%): 40 - 70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 hours light / 12 hours dark
IN-LIFE DATES: From: 1990-03-27 To: 1990-05-24
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% methylcelluose in distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 73.7, 100, 135.7, 1842 and 250 mg/mL
- Amount of vehicle (if gavage): 20 mL/kg body weight
- Justification for choice of vehicle: Commonly used vehicle for studies of this nature
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg body weight
DOSAGE PREPARATION (if unusual): Dissolution suspension in vehicle. Stability / homogeneity confirmed by analysis - Doses:
- 1474, 2000, 2714, 3684 and 5000 mg/kg body weight
- No. of animals per sex per dose:
- Five males and five females / dose group; 5 dose groups
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 5 times on day of dosing following dosing; twice daily thereafter for 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight: Weekly on Days 1, 8 and 15 - Statistics:
- Probit analysis by the method of Finney (1952) was used to determine the acute median lethal dosage, 95% confidence interval and slope of the dose response curve for both sexes.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 036 other: mg/Kg
- 95% CL:
- 1 607 - 2 465
- Remarks on result:
- other: slope (degrees): 73
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 322 other: mg/Kg
- 95% CL:
- 1 711 - 2 934
- Remarks on result:
- other: Slope (degrees):66
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 171 other: mg/Kg
- 95% CL:
- 1 789 - 2 552
- Remarks on result:
- other: Slope (degrees): 68
- Mortality:
- Animals died at dosages of 1474 mg/kg and above. The deaths occurred on Days 2, 3, 4 or 6.
1474 mg/kg bw - 1/5 males and 1/5 females
2000 mg/kg bw - 2/5 males and 0/5 females
2714 mg/kg bw - 4/5 males and 5/5 females
3684 mg/kg bw - 5/5 males and 5/5 females
5000 mg/kg bw - 5/5 males and 4/5 females - Clinical signs:
- other: Ante mortem signs comprised lethargy, decreased motor activity, prone posture, ataxia, muscle tremor, bradypnoea, hyperpnoea, piloerection, ungroomed appearance, pigmented staining of the snout, hunched posture, thin body conformation, diarrhoea and dark
- Gross pathology:
- Necropsy of the decedents revealed altered stomach, small intestine and caecum contents and areas of body staining and cannibalisation. Necropsy of the surviving animals revealed no significant macroscopic lesion.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of BTN/A following administration of a single dose to the rat is 2171 mg/kg body weight
- Executive summary:
Acute oral toxicity has been investigated using OECD/EU test methods. The median lethal dose (LD50) of the substance following administration of a single oral dose to the rat is 2171 mg/kg body weight
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