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EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Eye irritation
-The eye irritation study indicates that Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate is a irritant to rabbit eyes.
The eye irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate is a irritant to rabbit eyes.
Based on the descriptions of the lesions it is considered that IPETC/ O-isopropyl ethylthiocarbamate is classifiable as irritant according to EU criteria.
Skin irritation
The acute skin irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate caused moderate irritation.
Based on the descriptions of the lesions it is considered that Reaction mass of O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol is classifiable as moderately irritant according to EU criteria.
Respiratory irritation.
There were no treatment-related changes in the haematological or urinalysis values in any of the animals. No signs of irritation of respiratory tract and Nasal effects were observe
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Butan-1-ol (Butyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamatel. Therefore Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate .
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, Title 16, Section 1500.41
- Principles of method if other than guideline:
- Six rabbits were exposed to the test substance for 24 hours under occlusive conditions (Draize-Test). The animals were observed for 8 days.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: W. Ostrop breeding facility, Germany
- Weight at study initiation: 2.7 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 4-6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-18 °C
- Humidity (%): 40 %
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 8 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: flanks on an area of 8 x 8 cm on both sides
- % coverage: 2.5 x 2.5 cm
- Type of wrap if used: occlusive dressing
SCORING SYSTEM: edema and erythema formation graded from 0 to 4 (according to Draize) - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: only readings on shaved skin taken into account
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.17
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: only readings on shaved skin taken into account
- Interpretation of results:
- other: moderately irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The mean value for erythema formation was 4, the mean value for edema formation was 3.17. As no full thickness necrosis was reported, the test substance is considered as irritating to the skin.The acute skin irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate caused moderate irritation.
- Executive summary:
The acute skin irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate caused moderate irritation.
Reference
The mean value for erythema formation was 4, the mean value for edema formation was 3.17. As no full thickness necrosis was reported, the test substance is considered as irritating to the skin.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture ofI IPETC/ O-isopropyl ethylthiocarbamate Therefore, propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- study terminated at 14 days instead of 21 with complete revisibility only seen in 3 of 6 animals
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products, Inc. Denver, Pennsylvania
- Age at study initiation: 12 weeks
- Weight at study initiation: 2.25 to 3.06 kg
- Housing: Individual in suspended stainless steel cages
- Diet (e.g. ad libitum): Purina certified rabbit chow ad libitum
- Water (e.g. ad libitum): Automatic watering system (Elizabethtown watering company) ad libitum
- Acclimation period: 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-21
- Humidity (%): 40-60
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From: June/July 1986 To: September 29-1986 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): 100% - Duration of treatment / exposure:
- Single treatment
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 3/sex/group
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM: Draize Scale
I. CONJUNCTIVAE
A. Redness (refers to palpebral and bulbar conjunctivae
excluding cornea and iris)
Vessels normal 0
Some vessels definitely injected 1
Diffuse, crimson red, individual vessels not easily discernible 2
Diffuse beefy red 3
Q. Chemosis
No swelling 0
Any swelling above normal (includes nictitating membrane) 1
Obvious swelling with partial eversion of lids 2
Swelling with lids about half closed 3
Swelling with lids more than half closed 4
C. Discharge
No discharge 0
Any amount different from normal (does not include small amounts observed in inner canthus of normal animals) 1
Discharge with moistening of the lids and hairs just adjacent to lids
Discharge with moistening of the lids and hairs, and considerable area around eye 3
D. Necrosis or ulceration of palpebral and bulbar
conjunctivae or nictitating membranes
Not present 0*
Necrosis present N*
Ulceration present U*
Conjunctivae Score: (A + B + C) X 2 (maximum = 20)
* - Not included in Draize grading system
II. IRIS
A. Values
Normal 0
Markedly deepened folds, congestion, swelling, circumcorneal injection (any of these), iris still reacting to light (sluggish reaction is positive).1
No reaction to light, hemorrhage, gross destruction (any of these) 2
Iris Score: A X 5 (maximum = 10)
III. CORNEA
A. Opacity-degree of density (area most dense)
No opacity 0
Slight dulling of the normal luster +*
Scattered or diffuse areas of opacity, details of iris clearly visible 1
Easily discernible translucent area, details of iris slightly obscured.. 2
Nacreous areas, no details of iris visible, size of pupil barely discernible 3
Complete corneal opacity, iris not discernible 4
B. Area of cornea involved
Up to one quarter 1
Greater than one quarter, less than half 2
Greater than half, less than three quarters 3
Greater than three quarters .4
C. Stippling-area of pinpoint roughening
No stippling 0*
Up to one quarter 1*
Greater than one quarter, less than half 2*
Greater than half, less than three quarters 3*
Greater than three quarters 4*
D. Ulceration-absence of area of corneal epithelium
No ulceration P*
Up to one quarter :, 1*
Greater than one quarter, less than half 2*
Greater than half, less than three quarters 3*
Greater than three quarters 4*
Corneal Score: A X B X 5 (maximum = 80)
* - Not included in Draize grading system
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.67
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- ca. 23
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #6
- Time point:
- 24 h
- Score:
- ca. 25
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 24 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #1
- Time point:
- 14 d
- Score:
- ca. 2
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: study terminated at 14 days, however trend of reversibility was observed
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #2
- Time point:
- 14 d
- Score:
- ca. 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #3
- Time point:
- 14 d
- Score:
- ca. 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #4
- Time point:
- 14 d
- Score:
- ca. 2
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: study terminated at 14 days, however trend of reversibility was observed
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #5
- Time point:
- 14 d
- Score:
- ca. 2
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: study terminated at 14 days, however trend of reversibility was observed
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #6
- Time point:
- 14 d
- Score:
- ca. 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Ocular instillation of isopropyl alcohol (MRD-86-962) elicited conjunctival, corneal and iridial responses in all animals.
Conjunctival responses included redness, chemosis, clear/white discharge and conjunctival ulceration. Redness was noted in all animals from the 1 Hour observation through the Day 10 observation. The incidence of redness decreased after these observations and three animals were noted with redness at the Day 14 observation. Chemosis was noted in all animals from the 1 Hour observation through the 48 Hour observation. The incidence of chemosis declined after these observations and chemosis was not noted at the Day 14 observation. Clear and/or white discharge was noted in all animals at the 1 and 4 Hour observations. The incidence of discharge decreased after these observations and no discharge was noted by the Day 4 observation. Conjunctival ulceration was noted in five animals during the study.
Iridial responses were noted in all animals during the study with varying incidences at the different observation intervals. Iridial responses were not noted after the Day 7 observation.
Corneal responses included opacity, stippling and corneal ulceration. Corneal opacity was noted in five animals, stippling was noted in five animals and corneal ulceration was noted in all animals during the study. All animals were clear of corneal responses by Day 7.
Other observations noted during the study included dye retention of the nictitating membrane and conjunctiva, and conjunctival blistering.
Ocular irritation was most prominent from the 1 Hour through the Day 4 observations where the total Draize score ranged from 4 to 25. - Interpretation of results:
- other: irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The results demonstrate a trend in reversibility; however, the study was ended at the day 14 instead of day 21 and full reversibility may have been observed at day 21. The results of this study indicate that the substance is a irritant to rabbit eyes. Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate. Therefore Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate
- Executive summary:
The eye irritation study indicates that Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate is a irritant to rabbit eyes.
Reference
Animal |
Effect |
24 hrs |
48 hrs |
72 hrs |
24-72hr avg |
4 days |
7 days |
10 days |
14 days |
1 |
Cornea |
4 |
4 |
3 |
3.67 |
1 |
0 |
0 |
0 |
Iris |
1 |
1 |
1 |
1.00 |
0 |
0 |
0 |
0 |
|
Redness |
3 |
3 |
3 |
3.00 |
3 |
2 |
1 |
1 |
|
Chemosis |
3 |
3 |
3 |
3.00 |
1 |
1 |
1 |
0 |
|
2 |
Cornea |
4 |
2 |
0 |
2.00 |
0 |
0 |
0 |
0 |
Iris |
1 |
1 |
0 |
0.67 |
0 |
0 |
0 |
0 |
|
Redness |
3 |
3 |
3 |
3.00 |
3 |
1 |
1 |
0 |
|
Chemosis |
3 |
3 |
2 |
2.67 |
1 |
1 |
0 |
0 |
|
3 |
Cornea |
3 |
2 |
0 |
1.67 |
0 |
0 |
0 |
0 |
Iris |
1 |
1 |
1 |
1.00 |
0 |
0 |
0 |
0 |
|
Redness |
3 |
3 |
3 |
3.00 |
3 |
1 |
1 |
0 |
|
Chemosis |
2 |
1 |
1 |
1.33 |
1 |
1 |
0 |
0 |
|
4 |
Cornea |
0 |
0 |
0 |
0.00 |
0 |
0 |
0 |
0 |
Iris |
1 |
1 |
0 |
0.67 |
0 |
0 |
0 |
0 |
|
Redness |
3 |
3 |
3 |
3.00 |
3 |
1 |
1 |
1 |
|
Chemosis |
1 |
1 |
0 |
0.67 |
1 |
0 |
0 |
0 |
|
5 |
Cornea |
4 |
3 |
2 |
3.00 |
0 |
0 |
0 |
0 |
Iris |
1 |
1 |
1 |
1.00 |
1 |
1 |
0 |
0 |
|
Redness |
3 |
3 |
3 |
3.00 |
3 |
2 |
1 |
1 |
|
Chemosis |
3 |
2 |
1 |
2.00 |
1 |
1 |
0 |
0 |
|
6 |
Cornea |
2 |
1 |
0 |
1.00 |
0 |
0 |
0 |
0 |
Iris |
1 |
0 |
0 |
0.33 |
0 |
0 |
0 |
0 |
|
Redness |
3 |
3 |
2 |
2.67 |
2 |
2 |
1 |
0 |
|
Chemosis |
4 |
2 |
1 |
2.33 |
0 |
0 |
0 |
0 |
|
6-animal averages: Cornea Iris Redness Chemosis |
1.89 |
6 animals fully reversed |
6 animals fully reversed |
6 animals fully reversed |
3 animals fully reversed |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Eye irritation
-The eye irritation study indicates that Propan-2-ol (Isopropyl alcohol) as a main constituent IPETC/O-isopropyl ethylthiocarbamate is a irritant to rabbit eyes.
The eye irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/O-isopropyl ethylthiocarbamate is a irritant to rabbit eyes.
Based on the descriptions of the lesions it is considered that IPETC/O-isopropyl ethylthiocarbamate l is classifiable as irritant according to EU criteria.
Skin irritation
The acute skin irritation study indicates that Butan-1-ol (Butyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate caused moderate irritation.
Based on the descriptions of the lesions it is considered that IPETC/O-isopropyl ethylthiocarbamate l is classifiable as moderately irritant according to EU criteria.
Respiratory irritation.
The results of the study (Burleigh-Flayer H, Garman R, Neptun D, Bevan C, Gardiner T, Kapp R, Tyler T & Wright G 1997) indicate that Propan-2-ol (Isopropyl alcohol) as a main constituent of IPETC/ O-isopropyl ethylthiocarbamate has not an adverse effect at concentration of 5000 ppm on kidneys in rats. Macroscopic changes such as granular kidney were noted in males and females of 2500 and 5000 ppm groups. A number of non-neoplastic histopathological changes were observed, with the most significant being in the kidney. The only neoplastic change observed was in male rats and was an increase in interstitial cell adenomas of the testis considered to represent marked hyperplasia and not autonomous growth.
There were no treatment-related changes in the haematological or urinalysis values in any of the animals. No signs of irritation of respiratory tract and Nasal effects were observe
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the hazard assessment of IPETC/ O-isopropyl ethylthiocarbamate
in section 2.1 and 2.2. in IUCLID 6., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health” andaccording to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Skin Corrosivity C R35 Causes severe burns R34 Causes burns Skin Irritation Xi R38 Irritating to skin R43 May cause sensitization by skin contact Eye Irritation (Ocular Lesions) Xi R36 Irritating to eyes R36/38 - Irritating to eyes and skin R37 irritating to respiratory system R41 Risk of serious damage to eyes |
CLP |
Skin Corrosivity H314 Skin Corr 1A Causes severe skin burns and eye damage H314 Skin Corr 1B Causes severe skin burns and eye damage Skin Irritation H315 Skin Irrit. 2 Causes skin irritation H317 Skin Sens. 1 May cause an allergic skin reaction Eye Irritation (Ocular Lesions) Xi H319 Eye Irrit. 2 Causes serious eye irritation H318 Eye Dam. 1 Causes serious eye damage H335 STOT SE 3 May cause respiratory irritation
|
It is concluded that the substance IPETC/O-isopropyl ethylthiocarbamate meet the criteria to be classified for human health hazards for Dermal-local effect: R36/38 - Irritating to eyes and skin, H315 Skin Irrit. 2 Causes skin irritation, H319 Eye Irrit. 2 Causes serious eye irritation
It is concluded that the substance IPETC/O-isopropyl ethylthiocarbamate does not meet the criteria to be classified for human health hazards for respiratory irritation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.