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EC number: 294-954-7 | CAS number: 91771-61-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cymbopogon winterianus, Gramineae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- other: classification of constituents
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- ECHA database
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Calculation of classification for skin sensitisation
- Author:
- Royal HaskoningDHV
- Year:
- 2 017
- Bibliographic source:
- Not relevant
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage.
- GLP compliance:
- no
- Type of study:
- other: calculation
Test material
- Reference substance name:
- Cymbopogon winterianus
- IUPAC Name:
- Cymbopogon winterianus
- Reference substance name:
- 91771-61-8
- Cas Number:
- 91771-61-8
- IUPAC Name:
- 91771-61-8
- Details on test material:
- - Name of test material (as cited in study report): Cymbopogon winterianus
- Physical state: Liquid
- Analytical purity: Confidential information
- Lot/batch No.: Confidential information
- Expiration date of the lot/batch: Confidential information
- Storage condition of test material: Room temperature in the dark
Constituent 1
Constituent 2
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- other: Not relevant
In vivo (non-LLNA)
Results
- Remarks on result:
- other: not relevant
In vivo (LLNA)
Results
- Remarks on result:
- other: not relevant
Any other information on results incl. tables
The most important constituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317).
Applicant's summary and conclusion
- Interpretation of results:
- other: sensitising
- Remarks:
- based on CLP criteria
- Conclusions:
- The most important constituents are classified for skin sensitisation and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
- Executive summary:
The classification of constituents of Cymbopogon Winterianus was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/serious eye damage. The most importantconstituents with regard to skin sensitisation are 1,(+)-citronellal (CAS 2385-77-5), citronellol (CAS 1117-61-9) and geraniol (CAS 106-24-1), present at typical concentrations of 36.27%, 12.74% and 21.56% respectively. These are all classified as skin sensitiser (Skin Sens. 1 / H317) and are present well above the classification threshold of 1% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Cymbopogon Winterianus is also considered to be classified for skin sensitisation (Skin Sens. 1 / H317).
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