Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-722-6 | CAS number: 7704-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- In accordance with Section 1.2 of REACH Annex XI, testing does not appear to be scientifically necessary as the weight of evidence indicates no concern for reproductive (fertility) effects from sulfur (conclusions from EFSA evaluations on food additives of sulfur-containing substances and EPA assessments for sulfur oxides and Cosmetic Ingredient Review of Sodium Sulfate) and therefore further testing on vertebrate animals is not warranted.
Sulfur is an inorganic element, which in its various forms (elemental, oxidised and reduced) accounts for about 1.9% of the total weight of the earth. Sulfur-deficient environments are rare in nature with chronic exposure to sulfur being the natural state. It is generally recognised as safe (40 CFR §180.2) by the US EPA and "since it does not give rise to metabolites other than such are well known to be intermediary or end products of mammalian metabolic reactions, the intent of chronic testing requirements do not apply to elemental sulfur and its possible metabolites."
In general, sulfur is an essential element in the metabolism of all living organisms, thus chronic exposure to sulfur is the natural state. More specifically, sulfur is unreactive and insoluble. Systemic effects were absent after subacute and subchronic oral exposure and subacute dermal exposure. Although sulfur can be absorbed both dermally and orally, it is mainly expected to be rapidly excreted. In the main, elemental sulfur is expected to be metabolised by plants rather than animals, with human intake of sulfur usually in the form of sulfur-containing amino acids, as well as sulfates and sulfites that may be present in many foods and beverages. Sulfur is only metabolised by intestinal bacteria; there are indications of absorption of metabolites but which are most likely endogenous to the body (e.g. well known to be intermediary or end products of mammalian metabolic reactions). The expectation that no effects on developmental toxic effects will occur as a consequence of sulfur exposure is supported by the long-standing use of sulfur in topically applied, pharmaceutical formulations and as a pesticide and the absence of developmental toxicity.
The weight of evidence looks at the available data on the forms of sulfur expected to be relevant to man, i.e. oxides of sulfur, sulfates and sulfites.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Integrated Science Assessment for Sulfur Oxides – Health Criteria
- Author:
- United States Environmental Protection Agency
- Year:
- 2 017
- Bibliographic source:
- EPA/600/R-17/451 | December 2017 | www.epa.gov/isa
Materials and methods
Test guideline
- Guideline:
- other: review of tests by various methods on different sulfur containing substances
- GLP compliance:
- no
- Remarks:
- Review article; GLP not applicable
Test material
- Reference substance name:
- Sulfur
- EC Number:
- 231-722-6
- EC Name:
- Sulfur
- Cas Number:
- 7704-34-9
- Molecular formula:
- S
- IUPAC Name:
- sulfur
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Remarks on result:
- other: No adverse effects on reproduction parameters expected for sulfur containing compounds
Results (fetuses)
Effect levels (fetuses)
- Remarks on result:
- other: No adverse effects on reproduction parameters expected for sulfur containing compounds
Overall developmental toxicity
- Developmental effects observed:
- no
Applicant's summary and conclusion
- Executive summary:
The EPA concluded that the overall evidence was inadequate to infer a causal relationship between exposure to SO2 and reproductive and developmental outcomes, and that this was consistent with the conclusion reached in the 2008 ISA for Sulfur Oxides (U.S. EPA, 2008).
The Integrated Science Assessment conducted by EPA looked at both animal toxicological studies and human epidemiology studies, with brief summaries of the animal studies considered given below:
- CD-1 female mice were exposed at concentrations of 83.8 or 170 mg/m3 (wholde body) for gestation days 7-18. No significant effects on hte number of live pups born/litter were observed, but birth weight was reduced at the top dose.
Original study: Singh J. (1989). Neonatal development altered by maternal sulfur dioxide exposure. Neurotoxicology, 10, 523-527.
- CD-1 male and female mice (10/group/sex) were near-continuously exposed (80% of time) at concetrations of 13.1, 31.4 or 78.6 mg/m3 (whole body) from 9 days prior to mating until gestation day 12-14. Pups were fostered by unexposed dams at birth and evaluated at 2-18 days of age. Decreased food and water intake was noted for parental animals, but no effects were noted for reproductive parameters (including mating, successful pregnancies, litter sizes, sex ratio, birth weight, postnatal body weight gain, somatic and neurobehavioral development).
Original study: Petruzzi S; Dell’Omo G; Fiore M; Chiarotti F; Bignami G; Alleva E. (1996). Behavioural disturbances in adult CD-1 mice and absence of effects on their offspring upon SO2 exposure. Arch Toxicol, 70, 757-766.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.