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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-028-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Acute intraperitoneal LD50 in rat, Test n° 831156, TK 10417 (Irgafos TNPP)
- Author:
- Kobel
- Year:
- 1 983
- Bibliographic source:
- Ciba-Geigy Limited.
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(nonylphenyl) phosphite
- EC Number:
- 247-759-6
- EC Name:
- Tris(nonylphenyl) phosphite
- Cas Number:
- 26523-78-4
- Molecular formula:
- C45H69O3P
- IUPAC Name:
- Phenol, nonyl-, phosphite (3:1)
- Details on test material:
- other TS: Trisnonylphenyl phosphite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf(SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age at study initiation: 7-8 weeks - Weight at study initiation: 195 to 240 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80.
- Details on exposure:
- Single dose of 1000 mg/kg bw, by intraperitoneal injection.
- Doses:
- one single dose
- No. of animals per sex per dose:
- 10
- Control animals:
- other: needed for data submission
- Details on study design:
- - Duration of observation period following administration: Mortality and symptoms were observed daily for 14 days - Frequency of observations and weighing: 80 Animals were weighed at day 1, 7 and 14.- Necropsy of survivors performed: yes, the animals were submitted to a gross necropsy at the end of the observation period.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- Dyspnoea, exophtalmus, ruffled fur and curved body position were seen, being common symptoms in acute tests. Animals recovered within 12 days.
- Body weight:
- No data
- Gross pathology:
- At autopsy, peritoneal adhesions in the liver and spleen area were found in 8/10 animals.
Applicant's summary and conclusion
- Conclusions:
- LD50 (ip) >1000 mg/kg.
- Executive summary:
LD50 (ip) >1000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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