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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Few details are available, but the parameters are similar to OECD guideline. No information on test substance purity.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- IOnly male rats (strain not specified) were tested. No information on test substance purity. Insufficient detail on method in report to exclude other possible deviations.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): Salicylic acid
- Substance type: pure active substance
- Physical state: solid
- Stability under test conditions: data not available
- Storage condition of test material: data not available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: from 173g to 179g (mean body weight per group)
- Source, Age at study initiation, Fasting period before study, Housing, Diet, Water, Acclimation period: data not available
ENVIRONMENTAL CONDITIONS
- Temperature, Humidity, Air changes, Photoperiod: data not available
IN-LIFE DATES: data not available
Administration / exposure
- Route of administration:
- other: oral, probably gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
- Amount of vehicle (if gavage): data not available
- Justification for choice of vehicle: data not available
- Lot/batch no.: data not available
- Purity: data not available
MAXIMUM DOSE VOLUME APPLIED: data not available
DOSAGE PREPARATION: data not available - Doses:
- 464, 681, 1000 and 1470 mg/kg
- No. of animals per sex per dose:
- 5 male rats per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were weighted at study initiation (all groups) and termination (only the 464 mg/kg group).
They were observed for symptoms and mortality at 0-4h, 4-12h, 12-24h, and then after 2, 3, 4, 5, 6, 7 and 8-14 days
- Necropsy of survivors performed: yes - Statistics:
- data not available
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 891 mg/kg bw
- 95% CL:
- 699 - 1 140
- Mortality:
- Mortality was observed at 681 mg/kg (1 animal), 1000 mg/kg (3 animals) and 1470 mg/kg (5 animals) (see Table 1)
- Clinical signs:
- other: Hypoactivity, muscular weakness
- Gross pathology:
- In survivors, no significant effects were observed.
In decedents, an inflammation of gastrointestinal tract was observed.
Any other information on results incl. tables
Table 1: Onset of symptoms and mortality
Dosage mg/kg |
Conc. % |
Onset of Symptoms (S) Mortality (M) |
Cumulative Deaths |
Body weight g |
Time of recovery (Day) | |||||||||||
Hours |
Days |
|||||||||||||||
0-4 |
4-12 |
12-24 |
2 |
3 |
4 |
5 |
6 |
7 |
8-14 |
I |
T |
|||||
464 |
25 |
0 / 5 |
179 |
227 |
||||||||||||
681 |
25 |
S |
M (1) |
1 / 5 |
176 |
- |
Day 2 | |||||||||
1000 |
25 |
S |
M (1) |
M (1) |
M (1) |
3 / 5 |
173 |
- |
Day 5 | |||||||
1470 |
25 |
S |
M (2) |
M (2) |
M (1) |
5 / 5 |
175 |
- |
S: onset of symptoms
M: onset of mortality (number of animals)
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test substance is considered as harmful according to EU criteria and is classified in Category 4 according to the GHS (UN/EU)
- Executive summary:
The acute oral toxicity of salicylic acid (purity unknown) was tested in a test similar to OECD guideline 401. Five male Albino rats per group (4 groups) were administrated a single dose of the test substance in a corn oil suspension. The dose were 464, 681, 1000 and 1470 mg/kg bw. The animals were then observed for 14 days.
Under the conditions of this test, the LD50 was 891 mg/kg bw. Signs of intoxication were hypoactivity and muscular weakness. At necropsy, no significant findings were observed in survivors, whereas inflammation of the gastrointestinal tract was observed in decedents. Based on the results of this study, salicylic acid would be classified as harmful in male rats by oral route, according to the Directive (67/548/EEC) on dangerous substance.
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