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EC number: 241-774-1 | CAS number: 17796-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Statement of GLP compliance No. G-026
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(cyclohexylthio)phthalimide
- EC Number:
- 241-774-1
- EC Name:
- N-(cyclohexylthio)phthalimide
- Cas Number:
- 17796-82-6
- Molecular formula:
- C14H15NO2S
- IUPAC Name:
- N-(cyclohexylthio)phthalimide
- Details on test material:
- Test batch No.: 041/07
Active substance: 99,42 % weight
Weight loss: 0,08 % weight
Toluene insolubles: 0,05 % weight
Ash: 0,008 % weight
Melting point: first liquid 92,3°C
complete liquid 92,5 °C
Sieve retention: 2,0 mm 0 %
0,5 mm 0 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Housing
Animals were housed in cage on bedding in groups by 5 in romm No. 132 of experimental animal house. After applocation they were housed individually.
Environment
Environmental controls for the animal room will be set to maintain 22±2°C, a relative humidity of 55±5%. The temperature and relative humidity of air will be registered and the records maintained in animal house. A minimum of 10 air changes/hour, and artificial light regime 12 h light/12 h dark. The sanitation was made according to standard operation procedure (5).
Food and Water
A standard certified laboratory diet (supplier Top Dovo Dobrá Voda) was served ad libitum and unlimited supply of drinking water (5). The diet was routinely analysed by the manufacturer for nutritional components and environmental contaminants.
Acclimatisation
5 days before the beginning of treatment (1,6)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- male/female: 2000 mg/kg body weigh
- No. of animals per sex per dose:
- females:
1: 2000 mg/kg
2: 2000 mg/kg
3: 2000 mg/kg
male:
4: 2000 mg/kg
5: 2000 mg/kg
6: 2000 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: Animals were observed individually after dosing at least once during the first 30 minutes., periodically during the first 24 hours, with special attention given during the 4 hours, and daily thereafter, for a total of 14 days. All observations were systematically recorded, with individual records being maintained for each animal.
We used a separate OECD Guidance Document (7) for assessing of clinical signs and conditions associated with pain, suffering, and impending death.
Observations included chenges in skin and fur, eyes and mucons membranes, and also respiratory, circulatory, autonomic and central nervous systems, and somatomotor activity and behaviour pattern. Attention was directed to observations of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
- Frequency of observations and weighing:Individual body weights of animals were determinated shortly before the test article was administered and weekly thereafter.Weights chenges after first and second week after aplication were calculated and recorded.
- Necropsy of survivors performed: yes
Results and discussion
- Preliminary study:
- None of animals died or displaying any toxicity symptoms in first 4 hours either in 14 days observation period. All of animals gain body weight after first either after second week after administration of test article. They reached body weight gains from 5 to 40 g per week. None of animals dispayed any pathological lesions.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Unclassified
- Mortality:
- no
- Clinical signs:
- other: Animals were observed individually after dosing at least once during the first 30 minutes., periodically during the first 24 hours, with special attention given during the 4 hours, and daily thereafter, for a total of 14 days. All observations were system
- Gross pathology:
- All test animals were subjected to grass necropsy. All grass pathologicalchanges were recorded for each animal. Animals to be sacrificed were anesthetized, exsanguinated and necrospied according to standard procedures. Uthanasia and autopsy of animal (8).
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
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