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EC number: 240-085-3 | CAS number: 15956-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-20 to 2013-04-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- two vessels were set up in a parallel design at 20 ± 1.0 °C, each vessel was sampled several times instead of sampling one vessel at every point in time
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- two vessels were set up in a parallel design at 20 ± 1.0 °C, each vessel was sampled several times instead of sampling one vessel at every point in time
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2011-02-07
- Type of method:
- flask method
- Remarks:
- analysis via ICP-OES
- Water solubility:
- 11.2 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50 g/L
- Incubation duration:
- 32 d
- Temp.:
- 20 °C
- pH:
- >= 5.5 - <= 6.1
- Remarks on result:
- other: calculated dissolved 2-ethylhexanoic acid, manganese salt from day 31 until day 32, at a loading of 50 g/L
- Water solubility:
- 1.8 g/L
- Conc. based on:
- element
- Remarks:
- Mn
- Loading of aqueous phase:
- 8.05 g/L
- Incubation duration:
- 32 d
- Temp.:
- 20 °C
- pH:
- >= 5.5 - <= 6.1
- Remarks on result:
- other: dissolved Mn from day 31 until day 32, at a loading of 50 g 2-ethylhexanoic acid, manganese salt /L
- Details on results:
- Observations
During the study, undissolved test material was observed in the media in the flasks. After filtration, the solutions were clear. In order to verify this, the turbidity was measured in filtered samples .
Temperature
The temperature in the thermostatically controlled water bath was monitored by a Testo 175-T2 thermo datalogger. The mean temperature was 19.9 ± 0.3 °C.
Monitoring oxygen concentration
During the experimental performance of the test, the oxygen concentration in the acrylic glass box was monitored with a MICRO IV oxygen sensor prior and after sampling. The oxygen values (in %) remained around 0 %. Slightly negative values, though impossible, are due to measurement uncertainties of the device at 0 % oxygen.
Solution pH
Solution pH in test item containing vessels and method blanks ranged from 5.4 to 6.1. The temperature measured by the pH meter is not within 20.0 ± 1.0 °C. Considering the pH values the pH meter is calibrated every workweek and verified every working day. A calibration of the temperature was not performed because a Testo 175-T2 thermo data logger was applied during the test.
Turbidity
The turbidity was measured after centrifugation and filtration to verify that only dissolved calcium concentrations would get measured. The turbidity was always < 1 NTU, indicating that there was not any undissolved material and micelles did not form after the filtration and centrifugation step. Method blanks were only filtered and not centrifuged, because the turbidity measurements were always < 1 NTU.
Dissolved manganese concentrations
Dissolved manganese concentrations in method blanks were at least below the respective limits of quantification (LOQ =0.595– 1.74 µg Mn/L) of respective measurement series.
Test samples were diluted (dilution factor 10,000) so that the respective Mn concentrations would be in the calibrated range of the ICP-OES instrument. Constant manganese concentrations as defined by the study guideline OECD 105 and the Regulation 440/2008/EC A.6 were measured from day 31 until day 32. - Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The test item 2-ethylhexanoic acid, manganese salt has a water solubility of 11.2 ± 1.2 g/L at 20.0 ± 1.0 °C, pH 5.5 to 6.1.
Reference
Method validation summary
validation parameter |
results |
comment |
selectivity |
similar data with three different manganese wavelengths for ICP-OES method |
no interferences due to test media observed |
linearity |
applied calibration functions were linear |
correlation coefficient at least 0.998530 |
limits of detection |
0.198– 0.385 µg Mn/L |
|
limits of quantification (LOQ) |
0.595 – 1.15 µg Mn/L |
|
method blanks |
at least below LOQ of respective measurement series LOQ = 0.595 – 1.74 µg Mn /L |
|
accuracy and precision |
mean recovery for CRM TM‑15.2 (18.1 µg Mn /L): 103 ± 2 % (n = 14) |
for low concentration range |
accuracy and precision |
mean recovery for diluted CRM TM‑15.2 (9.05 µg Mn /L): 105 ± 6 % (n = 4) |
for low concentration range |
accuracy and precision |
mean recovery for diluted CRM TMDA-70 (30.2 µg Mn /L): 105 ± 2 % (n = 18) |
for concentration range |
accuracy and precision |
mean recovery for multielement standard solution XXI (100 µg Mn/L): 105 ± 2 % (n = 19) |
for higher concentration range |
accuracy and precision |
mean recovery for multielement standard solution XXI (50 µg Mn/L): 106 ± 2 % (n = 5) |
for concentration range |
accuracy and precision |
mean recovery for multielement standard solution XXI (10 µg Mn/L): 103 ± 1 % (n = 2) |
|
trueness |
recovery from fortification of samples: 102 – 105 % (n = 10) |
|
repeatability |
mean recovery for CRM TM‑15.2 (18.1 µg Mn /L): 103 ± 2 % (n = 14) |
for low concentration range |
repeatability |
mean recovery for diluted CRM TMDA-70 (30.2 µg Mn /L): 105 ± 2 % (n = 18) |
for concentration range |
repeatability |
mean recovery for multielement standard solution XXI (100 µg Mn/L): 105 ± 2 % (n = 19) |
for higher concentration range |
repeatability |
mean recovery for multielement standard solution XXI (50 µg Mn/L): 106 ± 2 % (n = 5) |
for concentration range |
Constant manganese concentrations were measured from day 31 until day 32, i.e. manganese concentrations varied were less than 15 % between sampling points and no increase of the water solubility were observed. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled. The mean dissolved manganese concentrations of solutions sampled from day 31 until day 32 were calculated.
Mean dissolved manganese concentrations day 31 – day 32:
Vessel 1: 1.6 ± 0.01 g Mn/L
Vessel 2: 2.0 ± 0.01 g Mn/L
The amount of 2-ethylhexanoic acid, manganese salt dissolved was calculated based on the metal content of the test substance as follows:
= mean of measured Mn concentration * 100 % / 16.1 % [Mn content of test item]
mean calculated manganese 2-ethylhexanoate dissolved day 31 – day 32:
Vessel 1: 9.9 ± 0.06 g/L
Vessel 2: 12.2 ± 0.06 g/L
Conclusion
Under the conditions of this test(under exclusion of CO2 and O2, under inert argon gas; flask method; loadings of and 50.0052 and 50.0164 g/L in vessel 1 and 2, respectively), a solubility equilibrium was reached from day 31 until day 32 of testing. The mean amount of dissolved Mn from day 31 until day 32 at 20.0 ± 1.0 °C is 1.8 ± 0.2 g/L (determined as dissolved Mn, separated by filtration from undissolved test item). This corresponds to a calculated water solubility of 2-ethylhexanoic acid, manganese salt of 11.2 ± 1.2 g/L, calculated based on a manganese content of 16.1 %. Solution pH in test item containing vessels and method blanks ranged from 5.5 to 6.1.
Description of key information
The test item 2-ethylhexanoic acid, manganese salt has a water solubility of up to 11.2 ± 1.2 g/L after 32 days at a loading of 50 g/L (20.0 ± 1.0 °C, pH 5.5 to 6.1).
Key value for chemical safety assessment
- Water solubility:
- 11.2 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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