Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-464-2 | CAS number: 121617-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Additional information
No studies on the toxicity of LAS-TEA to soil organisms were available. The toxicity of LAS-TEA to soil organisms may be described by the toxicity of LAS-Na and TEA according to the read-across statement in which full dissociation of the LAS-TEA in the environment is supported.
For LAS-Na a large number of terrestrial toxicity studies are available. No studies on terrestrial toxicity of TEA were available. The following data waiver for TEA was provided: 2,2',2''-nitrilotriethanol (TEA) is readily biodegradable and has a low adsorption potential (Koc= 17 L/kg, logKow = -2.3), therefore soil exposure via sewage sludge as an agriculture fertilizer is low. It does not have the potential to bioaccumulate nor is it considered as a PBT/vPvB substance. 2,2',2''-nitrilotriethanol is expected to rapidly degrade in soil, as indicated by a half-life of 1.8d determined in a degradation test in soil. Hence, soil is not expected to be a compartment of concern, therefore toxicity testing of soil macroorganisms, terrestrial arthropods and terrestrial plants can be waived.
A PNECsoil for LAS-NA was derived in the European Union (EU) Risk Assessment of LAS (Jensen et al , 2007). The EU undertook a review of studies on the toxicity of LAS to soil macro-organisms and terrestrial plants in order to determine a predicted level of no adverse effects (PNEC) in soil. Nine invertebrate studies and 12 plants studies were used to calculate the PNEC. Full references for all studies are provided in the dossier. In all the plant experiments, LAS was added as an aqueous solution, and the most sensitive endpoint - growth - was used in the PNEC calculation. In cases where an NOEC or EC10value was not reported, the original data or graphical estimations were used to calculate the EC10value. This was considered more appropriate than using an arbitrary extrapolation factor. Invertebrate data were based on 9 chronic studies. In cases where there was more than one study on a particular species, a geometric mean of the data was used. The data for both sets of studies were merged as the sensitivity of both types of species were similar. This was confirmed by the Kolmogorov-Smirnov test. The species sensitivity distribution was then calculated. From this, the concentration that would exceed NOEC or EC10 for 5% of species was calculated (HC5). Based on this information, the HC5was determined to be 35.3 mg/kg soil. The 95% confidence interval was 18.6-50.0 mg/kg. The PNEC for soil was determined to be 35 mg/kg. For completeness, the PNECsoil of 35 mg/kg is proposed for LAS-TEA.
PNEC-soil for LAS-TEA was derived on the basis of equilibrium partitioning method , and was as such considered to be less acurate than a PNEC derived from toxicity data as was done for LAS-Na. The PNEC-soil for TEA was not taken into account and the PNEC-soil derived for LAS-Na was used as estimate for the PNEC-soil for LAS-TEA. Differences in molar weight of LAS-Na and LAS-TEA were not taken into consideration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)