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EC number: -
CAS number: 37486-69-4
Three genetic toxicity
studies were conducted with and without metabolic activation according
to the guidelines noted above. In
all cases, no evidence of genotoxicity was seen. Control
materials induced the appropriate responses in all tests and the tests
were considered valid.
The bacterial reverse
mutation assay used S. typhimurium strains TA98, TA100, TA1535 and
TA1537 and E. coli strain WP2uvrA at TFEE-5 concentrations up to 5000
number of revertants did not increase more than 2-times (TA 100) or
3-times (other strains) the solvent control values at any TFEE-5
The chromosome aberration
assay used human peripheral lymphocytes at TFEE-5 concentrations up to
100 micrograms/ml (TFEE-5 precipitated at ≥100 micrograms/ml). TFEE-5
did not induce statistically significant increases in the number of
cells with chromosome aberrations at any concentration tested.
The mammalian cell gene
mutation assay used mouse lymphoma L5178Y cells at TFEE-5 concentrations
up to 100 micrograms/ml (TFEE-5 precipitated at ≥100 micrograms/ml). TFEE-5
did not induce reproducible mutant frequencies of at least 126 per
million cells greater than the solvent controls.
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