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Diss Factsheets
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- American Petroleum Institute (1980) Acute toxicity tests on API 79-6, diesel fuel (market place sample). Medical and Biological Sciences Dept. Report No. 27-32817
- Author:
- American Petroleum Institute
- Year:
- 1 980
- Bibliographic source:
- American Petroleum Institute
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Food was withheld from the rats overnight prior to dosing. A single dose of test material was given by gavage to groups of 5 male and 5 female rats at dose levels of 2.5, 5.0, 10, 15 & 20 ml/kg. Daily observations were made for death or signs of toxicity during the 14 day duration of the study. Body weights were recorded at the start and on the 7th and 14th day of the study.
A gross necropsy was performed on all animals that died during the study
and on all survivors that were sacrificed on day 14. - GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- API 79-6
- IUPAC Name:
- API 79-6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Doses:
- 2.5, 5.0, 10, 15 & 20 ml/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: oral median lethal dose
- Effect level:
- ca. 9 mL/kg bw
- Based on:
- not specified
- 95% CL:
- >= 5.58 - <= 14.51
Any other information on results incl. tables
Mortality rates were as follows:
Dose group (ml/kg) | Mortality (%) |
2.5 | 12.5 |
5 | 20 |
10 | 70 |
15 | 40 |
20 | 90 |
Signs of toxicity were the same for all dose groups and increased in severity with increasing dose. The signs included oily urine stains and oily diarrhea. The urine and feces stayed on the fur and caused hair loss, irritation, redness and sores on the affected skin. In many animal open sores were observed on the skin surrounding the anus. Blood around the eyes, nose and mouth was also common. Other signs noted included lethargy and pus or blood at the urinary orifice. Observations at gross necropsy were similar for each dose group. Almost all animals that died before the 14th day had intestinal damage. The intestines and often the stomach were hemorrhagic, sometimes observed with blood. The intestinal walls were thin. Test material was found in the cecum for many days after dosing and a few rats had white spots on their cecums and an increased amount of gas was noted in the intestinal tract. Animals surviving 14 days had fewer abnormalities, all minor in nature. These included enlarged Peyer's patches on the intestine, an indication that some irritation had occurred.
Applicant's summary and conclusion
- Conclusions:
- Although the study was conducted before Good Laboratory Practices were published, the study appears to have been conducted using appropriate methods and to have been fully reported.
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