Registration Dossier
Registration Dossier
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EC number: 604-958-6 | CAS number: 15448-47-2
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- propylene oxide
- IUPAC Name:
- propylene oxide
- Reference substance name:
- Methyloxirane
- EC Number:
- 200-879-2
- EC Name:
- Methyloxirane
- Cas Number:
- 75-56-9
- IUPAC Name:
- 2-methyloxirane
Constituent 1
Constituent 2
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Harris et al. (1989) investigated the potential developmental toxicity of propylene oxide by inhalation. Groups of 25 female F344 rats were exposed, whole body, to 0, 100, 300 and 500 ppm (0, 237, 711 and 1,188 mg/m3) for 6 hr.day, on gestation days 6 -15 inclusive. The incidence of foetal malformations was minimal and showed no relationship to exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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