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EC number: 700-957-0
CAS number: 1141852-17-6
Table 1. Results of eye irritation study (individual scores)
The eye irritation potential of Y-15866 was investigated in a
study according to OECD guideline 405 and in compliance with GLP. The
undiluted test substance (0.1 mL) was placed into the conjunctival sac
of the left eye of 3 young adult New Zealand White rabbits (1 male and 2
females). Scoring of irritation effects was performed approximately 1,
24, 48 and 72 h after test substance instillation. The instillation of
Y-15866 into the eye resulted in mild, early-onset and transient ocular
changes, such as reddening of the conjunctivae and sclerae, as well as
chemosis. These effects were reversible and were no longer evident up to
48 h after treatment. No abnormal findings were observed in the cornea
or for the iris light reflex of any animals at any of the examinations.
No corrosion and no staining of the treated eyes and no clinical signs
were observed. The individual mean scores after 24, 48 and 72 h for
corneal opacity and iris light reflex were 0 for all three animals. The
individual mean scores after 24, 48 and 72 h for the conjunctivae were
0, 0.33 and 0 for reddening, respectively, and 0 for chemosis for all 3
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