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EC number: 700-957-0
CAS number: 1141852-17-6
The skin irritation potential of Y-15866 was investigated in a
GLP-conform study according to OECD guideline 404. The undiluted test
substance (0.5 mL) was applied for 4 h to the clipped skin of 3 young
adult New Zealand White rabbits (1 male and 2 females) under
semiocclusive conditions. The scoring of skin reactions (erythema and
edema) was performed 1, 24, 48 and 72 h after removal of the dressing.
The test item did not elicit any skin reactions at the application site
of any animal at any of the observation time points. No signs of
systemic toxicity were seen. The mean erythema and edema scores over 24,
48 and 72 h were 0 for all 3 animals.
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