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EC number: 700-957-0
CAS number: 1141852-17-6
The acute oral toxicity of Y-15866 was investigated in a
GLP-conform study according to the acute toxic class method (OECD
guideline 423). Two groups, each consisting of 3 female RccHan:WIST
rats, were treated with Y-15866 diluted in PEG 300 as vehicle by single
oral gavage administration at a limit dose of 2000 mg/kg bw. The animals
were observed for clinical signs and mortality once before treatment,
within the first 30 min and at approximately 1, 2, 3 and 5 h after
treatment on Day 1. During the observation period of 14 days, animals
were inspected twice daily for mortality and once daily for clinical
signs. Body weights were recorded on Day 1 (prior to administration) and
on Days 8 and 15. All animals were necropsied and examined
macroscopically. No mortality occurred during the study period. Slightly
ruffled fur was observed in all 6 animals 2 h after test substance
administration. The ruffled fur persisted with the same severity in 2
animals at the 3 h reading. All 6 animals of groups 1 and 2 were free of
clinical signs from the 5 h reading to the end of the study (on Day 15).
The body weight of the animals was within the range commonly recorded
for this strain and age. No macroscopic findings were recorded at
necropsy. Based on these experimental results, the LD50 of Y-15866 was
greater than 2000 mg/kg bw. According to the criteria of OECD guideline
423, the LD50 cut-off of Y-15866 may be considered to be greater than
5000 mg/kg bw.
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