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EC number: 235-120-4
CAS number: 12070-08-5
No substance specific data on toxicity to reproduction is
available for titanium carbide. Due to similar physico-chemical
properties, similar or lower transformation/dissolution results and
similar or lower in vitro bioaccessibility in synthetic body fluids
compared to titanium dioxide, data from TiO2 can be used for read-across.
For the reasons presented above, conducting a developmental
toxicity study and two-generation reproduction toxicity study would not
provide any further insights in the toxicity of TiC. Because of the lack
of absorption and systemic distribution an exposure of the reproductive
organs in male and female rats to TiC is rather unlikely. Thus any
specific effects on reproduction are not to be expected. Therefore, it
is scientifically not justified to conduct a developmental toxicity
study and two-generation reproduction study in rats which complies with
the 3R-rules and the principles of animal welfare (in accordance with
Annex X, section 8.7, column 2 of regulation (EC) 1907/2006).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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