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EC number: 235-120-4
CAS number: 12070-08-5
Bioelution results of TiC in four artificial body fluids and an in vitro dermal absorption study according to OECD 428 conducted with TiO2.
Bioelution results of TiC in
four artificial body fluids have been conducted (Kirby Memorial Health
Center, 2012). These data support read-across between TiO2and
TiC. Only at very low pH values (gastric fluid, pH 1.5) the Ti-release
from TiC is higher compared to TiO2, but still at a low level
of 0.21% (2h). This difference is not considered to be relevant as TiO2did
not elicit toxicity after oral application of 3.500 mg/kg/d in a 2-yr
carcinogenicity study in rat (NCI 1979).
An in vitro dermal
absorption study according to OECD 428 was conducted with TiO2(Gamer
2006). No dermal absorption of Ti ions has been reported.
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