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EC number: 235-120-4
CAS number: 12070-08-5
Titanium carbide was not tested for short-term toxicity to fish, and read-across to titanium dioxide was used for this endpoint. No deaths were observed at saturation concentration under exposure conditions in acute and prolonged toxicity tests with titanium dioxide; a definitive LC50 could not be determined.
Wahrheit et al. (2007)
tested fine TiO2 (380 nm) and ultrafine TiO2 (140
nm) using rainbow trout as test organisms according to the protocol of
OECD guideline 203. Fish were exposed for 96 h at nominal test
concentrations up to 100 mg TiO2/L (both particle sizes). The
LC50 values for fine and ultrafine TiO2 for
rainbow trout were determined to be > 100 mg/L.
This result is further
supported by Griffitt et al. (2008) who did not observe toxic effects to
adult female zebrafish when exposed at nominal concentrations up to 10
mg/L TiO2 for 48 h.
In addition, TiO2
did not exhibit toxic effects in rainbow trout when fish were exposed
for 14 days at concentrations up to 1 mg/L (Frederici et al., 2007).
lower transformation/dissolution results for titanium carbide (the
target substance) than titanium dioxide (the source substance), the
resulting toxicity potential would also be expected to be lower.
Therefore, the dose descriptors are expected to be sufficiently high for
the target substance, and read-across to the source chemical is
adequately protective (for more details refer to the attached
description of the read-across approach). In
fact, (eco-)toxicologically relevant release of Ti ions from titanium
carbide is not expected as the concentration of soluble Ti ions was
below the method detection limit (< 0.4 µg/L) in the T/D test. Thus, TiC
in considered to be practically insoluble, hence release of Ti ions to
any ecotoxicologically relevant extent (and potential subsequent
formation of soluble and/or insoluble Ti compounds) is not expected.
Therefore, any short-term toxic effects to fish are not expected to
arise from TiC.
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