Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only orientating information about the inhalation hazard

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Principles of method if other than guideline:
The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle as described in OECD Guideline 403 and in accordance to Smyth et al., Am.Ind.Hyg.Ass.J. 23,95-107 (1962). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of the test substance at a temperature chosen for vapor generation (i.e. 20 °C for the present test substance).
The animals were exposed to the test substance for 7 hours (flow-through, 200 liters/hour).
GLP compliance:
no
Test type:
other: IHT
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
- Physical state: solid
- Composition of test material, percentage of components: TiO2: 78.9%, Sb2O5: 15.5%, NiO 4.1%, SiO2: 1.5% (crosscontamination with material from ball mill), As: 40 ppm, Pb: 130 ppm, Cu: 4 ppm, Zn: 10 ppm

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: air
Duration of exposure:
7 h
Details on study design:
12 animals of unknown sex were exposed.

Results and discussion

Mortality:
No mortality was observed throughout the study period.
Clinical signs:
Animals did not show any clinical signs related to test item exposure.
Body weight:
No data.
Gross pathology:
Nothing abnormal was detected during necropsy of the animals.

Applicant's summary and conclusion