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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only orientating information about the inhalation hazard

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle as described in OECD Guideline 403 and in accordance to Smyth et al., Am.Ind.Hyg.Ass.J. 23,95-107 (1962). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of the test substance at a temperature chosen for vapor generation (i.e. 20 °C for the present test substance).
The animals were exposed to the test substance for 7 hours (flow-through, 200 liters/hour).
GLP compliance:
no
Test type:
other: IHT
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Antimony nickel titanium oxide yellow
EC Number:
232-353-3
EC Name:
Antimony nickel titanium oxide yellow
Cas Number:
8007-18-9
IUPAC Name:
8007-18-9
Constituent 2
Reference substance name:
C.I. Pigment Yellow 53
IUPAC Name:
C.I. Pigment Yellow 53
Constituent 3
Reference substance name:
Sicotangelb AMFG (fest)
IUPAC Name:
Sicotangelb AMFG (fest)
Details on test material:
- Physical state: solid
- Composition of test material, percentage of components: TiO2: 78.9%, Sb2O5: 15.5%, NiO 4.1%, SiO2: 1.5% (crosscontamination with material from ball mill), As: 40 ppm, Pb: 130 ppm, Cu: 4 ppm, Zn: 10 ppm

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: air
Duration of exposure:
7 h
Details on study design:
12 animals of unknown sex were exposed.

Results and discussion

Mortality:
No mortality was observed throughout the study period.
Clinical signs:
other: Animals did not show any clinical signs related to test item exposure.
Body weight:
No data.
Gross pathology:
Nothing abnormal was detected during necropsy of the animals.

Applicant's summary and conclusion