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EC number: 429-330-7
CAS number: -
Assessment of acute oral toxicity with PDTN
in the rat (Acute Toxic Class Method).
The study was carried out based on the
guidelines described in EC Commission Directive 96/54/EC, Part B.1 tris
and OECD No.423. PDTN was administered by oral gavage to three Wistar
rats of each sex at 2000 mg/kg body weight. Animals were subjected to
daily observations and weekly
determination of body weight. Macroscopic
examination was performed on the day of death or after terminal
sacrifice 14 days after dosing. One female was found dead on day 3 (day
1 is day of dosing). Lethargy, hunched posture, piloerection, diarrhoea
and red staining of the snout were noted among the animals between days
1 and 3. The body weight gain shown by the surviving animals over the
study period was stated to be normal. However, a BW gain of 88 g in one week
for one of the males is not expected.
Macroscopic post mortem examination of the
animal that died revealed a hemorrhagic content of the urinary bladder.
No abnormalities were found in the surviving animals. The oral LD50 of
PDTN in Wistar rats was established as exceeding 2000 mg/kg body weight.
Based on these results and according to the OECD-GHS criteria for
classification, PDTN requires classification in Category 5.
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