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EC number: 259-393-4 | CAS number: 54914-37-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-06-12 to 1985-07-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1981)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine
- EC Number:
- 259-393-4
- EC Name:
- 1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine
- Cas Number:
- 54914-37-3
- Molecular formula:
- C18H34N2
- IUPAC Name:
- 1,3,3-Trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethanamine
- Test material form:
- other: liquid
- Details on test material:
- Produced October 1980. Purity 95 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3160; 3980; 5010; 6310 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 150 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 517 - <= 4 897
- Mortality:
- - Number of deaths at each dose:
3160 mg/kg bw: 0 males, 2 females dead within 26 hours
3980 mg/kg bw: 1 male, 4 females dead within 24 hours
5010 mg/kg bw: 2 males, 3 females dead within 48 hours
6310 mg/kg bw: 5 males, 4 females dead within 30 hours - Clinical signs:
- other: - 30 minutes after application: Ruffled fur - later: Crouched posture, some cases of slight sedation and ataxia, staggering gait, prone position, cyanosis of the extremities, hypothermia, and narrowed or closed palpebral fissures - at 24 hours (additi
- Gross pathology:
- - animals that died during the study: Swelling of the gastric mucosa, hyperemia of the gastric and intestinal mucosa, the peritoneum and the diaphragm, and of the pancreas; formation of flecks on liver and kidneys
- terminal necropsy: Areas of whitish fur on the cardial mucosa, discoloration of the liver, conglutination and fusion of the abdominal organs with one another and with the diaphragm
Applicant's summary and conclusion
- Conclusions:
- The LD50 value (oral) of 1,3,3 -Trimethyl-N-(2 -methylpropylidene)-5 -[(2 -methylpropylidene)amino]cyclohexanemethylamine in female and male rats was estimated to be 4150 mg/kg bw. Therefore, under the conditions employed in this study, the acute toxicity after oral exposure in rats is low.
- Executive summary:
1,3,3 -Trimethyl-N-(2 -methylpropylidene)-5 -[(2 -methylpropylidene)amino]cyclohexanemethylamine is of low oral acute toxicity with an oral LD50(rat) of 4150 mg/kg bw (OECD 401, Hüls AG, 1985). Mortalities were observed in the oral acute toxicity study at doses > 3160 mg/kg bw. Clinical signs after oral administration like ruffled fur 30 min after application, later: crouched posture, some cases of slight sedation and ataxia, staggering gait, prone position, cyanosis of the extremities, hypothermia, and narrowed or closed palpebral fissures. At 24 h additional observations, like diarrhea and increased diuresis were made. In the two highest dose groups (i.e. 5010 and 6310 mg/kg bw respectively), difficulties with breathing, uttering sounds when touched and towards the end of the study ruffled fur in 2 animals from the high dose group were observed. Other signs disappeared approximately by day 10.
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