Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Maleic Anhydride and Maleic Acid, SIDS Initial Assessment Report For SIAM 18
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- OECD SIDS Initial Assessment Report For SIAM 18, 20-23 April 2004
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline available found in the published report.
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- guinea pigs study
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- 2,5-dihydrofuran-2,5-dione
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: not available
- Vehicle:
- not specified
- Concentration / amount:
- not available
- Day(s)/duration:
- not available
- Adequacy of induction:
- not specified
Challenge
- Route:
- other: not available
- Vehicle:
- not specified
- Concentration / amount:
- not available
- Day(s)/duration:
- not available
- Adequacy of challenge:
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: not available
- Group:
- other: not available
- Dose level:
- not available
- Clinical observations:
- not available
- Remarks on result:
- other: not available
Applicant's summary and conclusion
- Conclusions:
- Maleic anhydride has been shown to be a skin sensitizer to guinea pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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