Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-687-6
CAS number: 909709-42-8
The test item was tested for its eye irritating potential with one
rabbit in a GLP study according to OECD GL 405. Prior to testing, a
hen's egg test on the chorioallantoic membrane was performed and no
irritating potential could be detected. For the test of primary eye
irritation, 100 mg of the test material was applied into the
conjunctival sac. The first examination of the eyes followed 1 hour
after instillation and the other examinations were performed daily for a
further 14 days.
There were no signs of pain immediately after instillation. The cornea
developed diffuse areas of opacity (scores 1) from the first reading up
to day 3 of the experimental part. At the iris signs of irritation were
observed (score 1) from the first reading up to day 4. The conjunctivae
showed redness (scores 1 and 2) and chemosis (score 1) from the first
reading up to experimental day 8. Thereafter no signs of irritation were
observed. The untreated eye was unchanged.
Based on the observed results the test item should be regarded as an
irritant to the eyes.
This GLP study was performed according to OECD GL 405. A eye
irritating potential was noted and the test item should be regarded as
an irritant to the eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again