Registration Dossier
Registration Dossier
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EC number: 806-543-7 | CAS number: 215917-77-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 200
- Temp.:
- 35 °C
- pH:
- 7
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.3
- Temp.:
- 35 °C
- pH:
- 7
- Details on results:
- The HPLC method at pH 7 was applied for the determination of partition coefficient (Pow) of the test substance. The calculation method was initially used as a preliminary estimation of the Pow of the test substance.
The results (Log Pow) of the Rekker calculation (calculation method) and the HPLC method differ by more than 0.3 log units. Since the HPLC method is a more accurate experimental method, the results of this are reported as the main endpoint for the determination of the partition coefficient. - Conclusions:
- The partition coefficient was determined to be 200 (Pow) and 2.3 (LogPow).
Reference
The Powand log Powvalue of the test substance was:
|
pH 7 |
||
Pow |
log Pow |
Area |
|
|
|
|
|
Test substance |
2.0x102 |
2.3 |
100 |
|
|
|
|
Description of key information
The HPLC method was applied for the determination of the partition coefficient (Pow) of the test substance.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.3
- at the temperature of:
- 35 °C
Additional information
The partition coefficient was determined to be 2.0 x 10^2 (Log Pow 2.3) using the HPLC method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
