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EC number: 274-288-3 | CAS number: 70049-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- activation of keratinocytes
Test material
- Reference substance name:
- 3-(aminosulphonyl)-4-chlorobenzoyl chloride
- EC Number:
- 274-288-3
- EC Name:
- 3-(aminosulphonyl)-4-chlorobenzoyl chloride
- Cas Number:
- 70049-77-3
- Molecular formula:
- C7H5Cl2NO3S
- IUPAC Name:
- 4-chloro-3-sulfamoylbenzoyl chloride
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vitro / in chemico
Resultsopen allclose all
- Key result
- Run / experiment:
- other: Mean of the 3 repetitions
- Parameter:
- other: Positive Control (PC) (Cinnamic aldehyde) induction > o igual 1.5-fold in at least one concentration
- Value:
- 1.518
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other:
- Remarks:
- 1.518 at 8 microM 2.664 at 16 microM 5.019 at 32 microM 11.866 at 64 microM 20.861 at 128 microM
- Key result
- Run / experiment:
- other: Mean of the 3 repetitions
- Parameter:
- other: Average induction of PC at 32 microM is 1.6-3.0
- Value:
- 5.02
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: All other aceptance criteria are met, and there is dose-dependent increase of induction with the Positive Control therefore, the results are considered as valid
- Key result
- Run / experiment:
- other: Mean of the 3 repetitions
- Parameter:
- other: EC1.5 value is 6-39 microM
- Value:
- 7.87
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Run / experiment:
- other: Mean of the 3 repetitions
- Parameter:
- other: CV% of blank values < 20%
- Value:
- 15.73
- Negative controls validity:
- not valid
- Positive controls validity:
- not valid
Applicant's summary and conclusion
- Interpretation of results:
- other: The result of the KeratinoSens skin sensitisation assessment of Cloruro Del Acido was Positive
- Conclusions:
- The result of the KeratinoSens skin sensitisation assessment of Cloruro Del Acido was Positive
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