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EC number: 695-797-0
CAS number: 93601-86-6
Mean tissue viability for the test
substance was > 50%, therefore the test substance is considered not to
be irritant to the skin.
In an in vitro skin irritation test
using a human skin model (EPISKIN Small Model), conducted according to
OECD 439 and GLP principles, the influence of the substance on the
viability of human skin was tested. Reliable positive and negative
controls were included. The test substance was applied directly to 0.38
cm2 cultured skin (11.6 to 11.7 mg, in presence of 5 μL Milli-Q water).
After 15 minutes, the substance was removed and cells were cultured for
42 hours. The viability of the cells was tested by reduction of MTT.
Skin irritation is expressed as the remaining cell viability after
exposure to the test substance. Survival of unexposed skin was set at
100%, the positive control had a mean cell viability of 6% whereas the
test substance showed cell viability of 143%. Since the mean relative
tissue viability after exposure to the test substance was above 50%, it
is concluded that the substance is not irritating in the in vitro skin
irritation test. Based on the
results, the substance does not need to be classified for skin
irritation according to Regulation (EC) No. 1272/2008 (CLP Regulation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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