Registration Dossier
Registration Dossier
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EC number: 605-076-4 | CAS number: 156928-09-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-08-21 to 2007-11-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Remarks:
- The testing facility indicated that the protocol was followed without deviation.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Remarks:
- The testing facility indicated that the protocol was followed without deviation.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Federal Office of Environment, Water Management and Supervision of Trade
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Identity: TIC876 (T002675)
- Batch: 603T-1
- Purity: 97.76%
- Expiration date: December 19, 2007
- Storage: at room temperature (about 20°C) - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.055
- pH:
- 5
- Remarks on result:
- other: The nominal temp of the HPLC system was 22.0°C with 5.0°C and 85.0°C as lower and upper limit respectively
- Details on results:
- Using the correlation log K/ log Pow, the log Pow of the test item T002675 was calculated as 1.055 ± 0.004.
- Conclusions:
- The log Pow of the test substance was found to be 1.055 ± 0.004 at pH 5.
Reference
Table 2. Test Substance Calculated Values
| Measurement | K | log K | log Pow |
| Measurement 1 | 0.5513 | -0.259 | 1.051 |
| Measurement 2 | 0.5559 | -0.255 | 1.058 |
| Measurement 3 | 0.5549 | -0.256 | 1.057 |
| Mean | 1.055 |
||
| Standard Deviation | 0.004 |
Description of key information
The log Pow of the substance was determined according to the OECD Guideline 117 and the EU Method A.8 and was estimated to be 1.055 at pH 5 (K1, Paulus, 2007).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.055
Additional information
The HPLC method was used to determine the partition coefficient of the substance. Using the correlation log K/ log Pow and based on the mean of three measurements, the log Pow of the test item T002675 was calculated as 1.0055 ± 0.004.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
