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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bornan-2-one
EC Number:
200-945-0
EC Name:
Bornan-2-one
Cas Number:
76-22-2
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration of treatment / exposure:
7 days/week, 13 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
600mg/kg/d, 120mg/kg/d, 25mg/kg/d, 0mg/kg/d
Basis:
nominal in diet
No. of animals per sex per dose:
12 females, 12 males

Examinations

Observations and examinations performed and frequency:
observe the performances envey morning and afternoon

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
no effects observed
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
no effects observed
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Description (incidence and severity):
organ coefficient is increased in spleen, kidney and brain

Effect levels

open allclose all
Dose descriptor:
NOEL
Effect level:
25 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
body weight and weight gain
Dose descriptor:
NOAEL
Effect level:
3.2 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
clinical signs

Target system / organ toxicity

Critical effects observed:
yes
Lowest effective dose / conc.:
9.9 mg/kg bw/day (nominal)
System:
hepatobiliary
Organ:
brain
heart
kidney
liver
spleen
Treatment related:
yes
Dose response relationship:
yes

Applicant's summary and conclusion