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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset for the CAS: 90604-31-2
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 84/449/EEC, B.5 "Acute toxicity (eye irritation)"
Principles of method if other than guideline:
The ocular irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.5 "Acute toxicity (eye irritation)"
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C13-15
EC Number:
292-324-6
EC Name:
Alcohols, C13-15
Cas Number:
90604-31-2
Molecular formula:
C15H32O
IUPAC Name:
Alcohols, C13-15
Test material form:
liquid
Details on test material:
- Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula:C13H280 + C15H32O
- Molecular weight: 208.78 g/mole
- Substance type: Organic
- Physical state: Liquid
- SMILES:CCCCCCCCCCCCCO
Specific details on test material used for the study:
- Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula: C13H280 + C15H32O
- Molecular weight: 208.78 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vitro

Other effects / acceptance of results:
No data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Alcohols, C13-C15 did not cause any severe reactions to rabbit eyes.
Hence, Alcohols, C13-C15 can be considered to be not irritating to eyes.
Executive summary:

The ocular irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.5 "Acute toxicity (eye irritation)".

Alcohols, C13-C15was instilled into the eyes of rabbits and observed for signs of irritation (dose, duration and observation period not mentioned).

Alcohols, C13-C15 did not cause any severe reactions to rabbit eyes.

Hence, Alcohols, C13-C15 can be considered to be not irritating to eyes.