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EC number: 402-470-6 | CAS number: 87172-89-2 CINEOLE ALCOHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-02-07 to 1986-03-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Cas Number:
- 87172-89-2
- IUPAC Name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Young adult male and female Sprague-Dawley rats were obtained from Charles River Breeding Laboratories, Inc., Wilmington, MA.
- Age at study initiation: Young adult
- Weight at study initiation: males: 195.8 to 221.8 g; females: 204.0 to 224.6 g
- Fasting period before study: Yes. Animals were fased overnight (approximately 18 hours) prior the test.
- Housing: Animals were individually housed in wire mesh bottom cages.
- Diet: NIH open formula 07, certified feed (Zeigler Brothers, Inc., Gardners, PA); ad libitum
- Water: Fresh tap water; ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 900, 1046, 1216, 1643, 2220 and 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighted on the day of dosing (day 1) and on day 8 and 15 of the study. All animals will be observed for mortlity and toxic signs frequently during the day of dosing and twice daily (at least 5 hours apart) thereafter for a toal of 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, cage side observations will include changes in the fur and skin; eyes and mucous membranes; respiratory, circulatory, autonomic and central nervous systems; somatomotor activity and behavior pattern, observation of tremors, convulsions, salivation, diarrhea, lethargy, and coma.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 429 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 169 - <= 1 689
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 053 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 952 - <= 1 154
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 293 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 123 - <= 1 464
- Mortality:
- All male rats died in the two highest dose groups of 2220 and 3000 mg/kg. All female animals died in the four highest dose groups. For details see table 1 in the section 'Any other information on results incl. tables'.
- Clinical signs:
- See table 1 in the section 'Any other information on results
- Gross pathology:
- See table 2 in the section 'Any other information on results
Any other information on results incl. tables
Table 1: Incidence of daily observations
Dose Level mg/kg |
Observations |
No. Affected/No. Examined |
|
Males |
Females |
||
900 |
Ataxia |
5/5 |
5/5 |
Decreased activity |
4/5 |
5/5 |
|
Salivation |
1/5 |
3/5 |
|
Lacrimation |
0/5 |
4/5 |
|
Appears to have blood in urine |
0/5 |
1/5 |
|
Wet abdomen |
0/5 |
3/5 |
|
1046 |
Ataxia |
4/5 |
5/5 |
Decreased activity |
2/5 |
5/5 |
|
Salivation |
2/5 |
1/5 |
|
Lacrimation |
1/5 |
4/5 |
|
Appears to have blood in urine |
0/5 |
1/5 |
|
Wet abdomen |
0/5 |
4/5 |
|
Hair loss-abdomen |
0/5 |
1/5 |
|
Death |
1/5 |
2/5 |
|
1216 |
Ataxia |
4/5 |
4/5 |
Decreased activity |
3/5 |
5/5 |
|
Salivation |
2/5 |
3/5 |
|
Appears to have blood in urine |
1/5 |
0/5 |
|
Lacrimation |
1/5 |
4/5 |
|
Wet abdomen |
1/5 |
0/5 |
|
Death |
1/5 |
5/5 |
|
1643 |
Ataxia |
4/5 |
1/5 |
Decreased activity |
4/5 |
5/5 |
|
Salivation |
1/5 |
3/5 |
|
Wet abdomen |
1/5 |
0/5 |
|
Lacrimation |
1/5 |
3/5 |
|
Death |
3/5 |
5/5 |
|
2220 |
Salivation |
4/5 |
3/5 |
Decreased activity |
5/5 |
5/5 |
|
Ataxia |
1/5 |
2/5 |
|
Lacrimation |
0/5 |
3/5 |
|
Death |
5/5 |
5/5 |
|
3000 |
Decreased activity |
5/5 |
5/5 |
Ataxia |
2/5 |
3/5 |
|
Salivation |
2/5 |
2/5 |
|
Lacrimation |
0/5 |
1/5 |
|
Death |
5/5 |
5/5 |
Table 2: Incidence of Necropsy Findings
Dosage Level mg/kg |
Findings |
No. Affected/No. Examined |
|
Males |
Females |
||
900 |
No noteworthy findings |
2/5 |
5/5 |
Lungs: multiple dark spots |
3/5 |
0/5 |
|
1046 |
No noteworthy findings |
4/5 |
3/5 |
Thoracic cavity: contains bloodlike liquid |
1/5 |
0/5 |
|
Lungs: dark and/or red areas |
1/5 |
1/5 |
|
Liver: pale |
0/5 |
1/5 |
|
Bladder: contains bloodlike liquid |
0/5 |
1/5 |
|
1216 |
External appearance: corneal opacity (left eye) |
0/5 |
2/5 |
No noteworthy findings |
4/5 |
0/5 |
|
Lungs: puffy (dark) |
1/5 |
2/5 |
|
Thymus: red spots |
1/5 |
3/5 |
|
Liver: dark |
1/5 |
4/5 |
|
Stomach (pyloric region): small red nodule |
1/5 |
1/5 |
|
Stomach (pyloric region): red |
0/5 |
1/5 |
|
1643 |
External appearance: corneal opacity (right eye) |
1/5 |
0/5 |
No noteworthy findings |
2/5 |
1/5 |
|
Thymus: red spot |
1/5 |
0/5 |
|
Lungs: puffy |
3/5 |
0/5 |
|
Lungs: dark red areas |
0/5 |
1/5 |
|
Lungs: pale |
1/5 |
0/5 |
|
Liver: dark |
3/5 |
3/5 |
|
Stomach (pyloric region): rad nodule |
1/5 |
0/5 |
|
Stomach (pyloric region): red |
1/5 |
0/5 |
|
2220 |
External appearance: corneal opacity (left eye) |
0/5 |
1/5 |
Liver: dark |
4/5 |
5/5 |
|
Lungs: puffy |
1/5 |
2/5 |
|
Lungs: pale |
1/5 |
0/5 |
|
Lungs: dark spots |
1/5 |
0/5 |
|
Thymus: red spots |
0/5 |
2/5 |
|
Stomach (pyloric region): red areas |
0/5 |
1/5 |
|
3000 |
External appearance: corneal opacity (left eye) |
0/5 |
1/5 |
Lungs: puffy (pale) |
4/5 |
4/5 |
|
Liver: dark |
5/5 |
5/5 |
|
Thymus: red spots |
0/5 |
1/5 |
|
Stomach 8pyloric region). Red areas |
0/5 |
1/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.