Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-539-1
CAS number: 6598-63-6
used as a test material to evaluate its skin sensitization potential.
The test was performed on 3 young
adult male New Zealand White rabbits weighing 2.2 to 2.3 kg. They were
housed individually in metal cages, were kept at a constant room
temperature of 20±3 °C, at a relative humidity of 30-70%, and on a 12
hours light cycle day. The animals received ad libitum standard pelleted
rabbit food (Nafag No. 814; Gossau, Switzerland) and water. Prior to
treatment they were acclimatized for a minimum of 5 days. The test
article was applied as a liquid formulation containing 21.3% FWA-5 in
24-hours before treatment an area of about 6 sq. cm was shaved on both
flanks of each rabbit. Gauze patch of 2.5 x 2.5 cm covered with 0.5 mL
of the test material was applied to one flank and a control patch to the
contralateral flank. The patches were covered with an impermeable
material and were fastened to the body of the rabbit with adhesive tape.
The duration of treatment was four hours. The scoring of skin reaction
was performed 1, 24, 48 and 72 hours after removal of the dressing.
These scores were used in calculating the respective mean values for
each type of lesion.
one hour, erythema was observed in each animal (one with grade 2; two
with grade 1) as was grade 1 edema. At 24-hours, no signs of erythema or
edema were observed and the calculated primary irritation index was 0.00
(max.8.0). The substance did not cause any staining of the treated skin.
No corrosive effects were noted on the treated skin of any animal at any
applied on the skin ofNew
Zealand White rabbits in concentration 0.5ml of 21.3%
in water . No corrosive effects were noted on the treated skin of any
animal at observation time.(Disodium
considered to be not irritating to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again