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EC number: 244-435-6 | CAS number: 21544-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 21 May 2014 and Experimental Completion date: 24 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 12.9 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value is not available
- Details on results:
- Please see "any other information on result incl. tables" field.
- Conclusions:
- The water solubilty of the test item has been determined to be 12.9 g/L of solution at 20.0 +/- 0.5 °C.
- Executive summary:
Water solubilty: 12.9 g/L of solution at 20.0 +/- 0.5 °C using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) N°440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Preliminary Test:
The preliminary estimate of water solubility was 7.56 g/L at 20.0°C
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution | Mean Peak area |
Standard 2.52 x 10E3 mg/L | 2.3267 x10E7 |
Standard 2.55 x 10E3 mg/L | 2.3378 x10E7 |
Matrix blank | None detected |
Sample 1A | 2.9313 x10E7 |
Sample 1B | 2.9346 x10E7 |
Sample 2A | 3.0322 x10E7 |
Sample 2B | 3.0225 x10E7 |
Sample 3A | 2.9361 x10E7 |
Sample 3B | 2.9427 x10E7 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample number | Time shake at ca. 30°C (hours) | Time equilibrated at 20°C (hours) | Concentration (g/L) | Solution pH |
1A | 24 | 24 | 12.8 | 7.48 |
1B | 24 | 24 | 12.8 | 7.48 |
2A | 48 | 24 | 13.2 | 5.91 |
2B | 48 | 24 | 13.2 | 5.91 |
3A | 72 | 24 | 12.8 | 7.52 |
3C | 72 | 24 | 12.8 | 7.52 |
Mean concentration: 12.9 g/L at 20°C +/- 0.5°C
Range: 12.8 to 13.2 g/L
Standard deviation: 0.229
VALIDATION:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 1.51 x10E3 to 1.51x10E4 g/L. This was satisfactory with a correlation coefficient (r) of 0.9993 being obtained.
DISCUSSION:
Peaks observed in the sample chromatography at retention times of approximately 4.3 and 4.6 minutes were considered to be most likely due to water soluble impurities in the test item and were not included in the water solubility calculation.
On completion of the equilibration period, the samples were clear and colorless with excess test item present at the bottom of the test vessels. After filtration through 0.45 microm filters, the supernatant was visually observed to be clear/colorless and free from un-dissolved test item.
The correlation coefficient (r) of the calibration curve was 0.9993 (optimum 1.0000). This reflects the linearity of the HPLC within the calibration range of 1.51 x10E3 to 1.51x10E4 g/L of the test item.
All individual water solubility results were within +/- 15% of the mean, thus satisfying the criteria specified in the guidelines.
The water solubilty of the test item has been determined to be 12.9 g/L of solution at 20.0 +/- 0.5 °C.
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 12.9 g/L
- at the temperature of:
- 20 °C
Additional information
Water solubilty:12.9 g/L of solution at 20.0 +/- 0.5 °C using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) N°440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
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