Registration Dossier
Registration Dossier
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EC number: 811-711-8 | CAS number: 14952-06-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February - March 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute toxicity LD50 range finding study
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (E)-methyl non-2-enoate
- EC Number:
- 811-711-8
- Cas Number:
- 14952-06-8
- Molecular formula:
- C10H18O2
- IUPAC Name:
- (E)-methyl non-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: SPF albino Fu
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1000, 2000, 4000, 8000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 8 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0 deaths occured
- Clinical signs:
- Principal toxic effect: reduced breathing rate @ 8 g/kg
Any other information on results incl. tables
After 1000 to 4000 mg/kg (oral) the animals cannot be distinguished from the controls. At 8000, the breathing rate is reduced, control appearance being regained by the 24th hour after administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
It was concluded that the LD50 of Neofolione was greater than 8000 mg/kg/bw.
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