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EC number: 226-942-4 | CAS number: 5570-77-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL
Data source
Reference
- Reference Type:
- publication
- Title:
- Subchronic inhalation of triethylamine vapor in Fisher-344 rats: organ system toxicity
- Author:
- NTRL
- Year:
- 1 987
- Bibliographic source:
- NTRL ,source; OTS0515254, 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- To evaluate the toxic potential of Triethylamin in Fischer 344 male and female rats by chronic inhalation.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- N,N-diethylethanamine
- Details on test material:
- - Name of test material (as cited in study report): Triethylamin
Substance Type : Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Triethylamin
Purity ; 99.9%
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Details on species / strain selection:
- Weanling caesarean-derived Fisher F344 [CDF (F-344)/Crl BR]Rats were screened for serological evidence of Mycoplasma pulmonis infection prior to the initiation of exposures and all results were negative.-
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Charles River breeding Laboratories, Wilmington MA- Age at study initiation: not reported- Weight at study initiation: not reported
- Fasting period before study: no
- Housing: individually
- Diet (e.g. ad libitum): PURINA LABORATORY CHOW. RALSTON PURINA. ST. LOUIS, MO ad libitum, except during the exposure periods
- Water (e.g. ad libitum): tap water ad libitum ; except during the exposure periods
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23±3°C
- Humidity (%):50±lO% R
- Air changes (per hr): 12-15/hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Remarks on MMAD:
- Not specified.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION- Exposure apparatus: Exposures were conducted in three 4.5 m³ stainless steel and glass inhalation chambers (Hinners et al., 1968) operated under dynamic flow conditions.- Temperature, humidity in air chamber: 23 ± 3°C and 50 ± 10% RH, respectively.- Air flow rate: 12-15 air changes per hr- Treatment of exhaust air: A fresh batch of TEA was used in the generation reservoir each day.
TEST ATMOSPHERE- Brief description of analytical method used: Wilks-Miran 1A Infrared Analyzer (Foxboro Analytical, Norwalk, CT) using the following instrument settings: wavelength 9 µm, pathlength 6.2 m, slit 1.0 mm. The instrument was calibrated by the closed loop calibration method. Adjustments were made to the generation system, as required, to maintain the exposure levels at the targeted concentrations.- Samples taken from breathing zone: yes. TEA concentrations in the chamber were monitored 2-4 times per hour using a Wilks-Miran 1A Infrared Analyzer (Foxboro Analytical, Norwalk, CT)
VEHICLE (if applicable) no - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- 2-4 times/hour with a Wilks-Miran Infrared Analyzer
- Duration of treatment / exposure:
- 28 weeks
- Frequency of treatment:
- 6 hours/day, 5 days/week 127 maximum exposure days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm (nominal)
- Remarks:
- (0 mg/m3)
- Dose / conc.:
- 25 ppm (nominal)
- Remarks:
- 103 mg/m3
- Dose / conc.:
- 247 ppm (nominal)
- Remarks:
- 1020 mg/m3
- No. of animals per sex per dose:
- 50/sex/dose
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: Exposure concentrations were selected to provide comparisons to previous toxicity determinations conducted in this laboratory with diethylamine at 25 and 250 ppm (Lynch et al., 1986).
- Rationale for animal assignment (if not random): randomised - Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- Observations and examinations performed & frequency
CAGE SIDE OBSERVATIONS: Yes
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: twice daily
BODY WEIGHT: Yes
- Time schedule for examinations: The day preceding the first day of exposure and at 2-week intervals throughout the study
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data available.
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data available.
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data available.
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data available.
OPHTHALMOSCOPIC EXAMINATION: No data available.
HAEMATOLOGY: Yes
- Parameters checked in table [No.?] were examined; Hemoglobin, hematocrit, complete blood count and differential count.
CLINICAL CHEMISTRY: Yes
- Parameters checked in table [No.?] were examined. Alanine
aminotransferase ,Aspartate aminotransferase, creatine
phosphokinase ,blood urea nitrogen (bun), creatinine (cre) and
sorbital dehydrogenase
Organ weight: Yes
URINALYSIS: Not specified
NEUROBEHAVIOURAL EXAMINATION: Not specified
OTHER: ECG were observed from 10 anesthetized rats/sex/group
cketamine/xylazine, ip) at the terminal sacrifice. data were recorded with rats lying in a prone position using an electronics for medicine dr-12 photographic oscillograph (white plains, ny). ecg waveforms were sampled and analyzed using a healthgard cpt-s computer system (salt lake city, ut).leads i, ii and iii. avr. avl, and AVF were recorded from each animal for five sec durations. heart rate, axes and amplitudes of the P wave. QRS complex, and T wave, as well as durations of various intervals. Were computed and compared among exposure groups. Each ECG tracing was also evaluated "in blind" by a veterinary cardiologist. - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes , Ten male and ten female rats were randomly- selected and sacrificed (35 mg/kg
pentobarbital sodium. ip after 30 and 60 days of exposure, 20 after 125 days of exposure (10 in controls) . Prior to sacrifice they were fasted overnight.A complete gross necropsy was performed and lungs, liver, kidney, and heart were weighed.
Histopathology: Yes ,lungs, liver, heart, spleen, kidneys, tracheobronchial lymphnodes, adrenals, urinary bladder, testes, seminal vesicles, uterus, ovaries, trachea, eyes, nasal passages were observed. - Statistics:
- t-test, multivariate analysis of variance, Kruskal-Wallis and chi-square test
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- At 247 ppm animals closed eyes and noses buried in fur in treated group .No statistically significant effect were observed at the dose level of 25 ppm in treated group compare to control.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- 1 female at 25 ppm (week 6), 1 male(week 8) and 2 females (week 3)(both accidentally) at 247 ppm Clinical .No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- effects observed, treatment-related
- Description (incidence and severity):
- Electrophysiology; No statistically significant effect were observed at the dose level of 25 and 247 ppm in treated group compare to control.
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 25 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- clinical biochemistry
- clinical signs
- gross pathology
- haematology
- mortality
- neuropathology
- organ weights and organ / body weight ratios
- other: ECG
- Remarks on result:
- other: No inhalatory toxic effect were observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The NOAEC was also refered as 103.3 mg/m³(25 ppm) as per study .
Applicant's summary and conclusion
- Conclusions:
- NOAEC was considered to be 25 ppm (corresponds to 103.3 mg/m³) for Triethylamin(121-44-8) in male and female F-344 rats by oral inhalation.
- Executive summary:
A repeated inhalation study for Triethylamin was conducted inmale and female F-344 rats . They were exposed at 0, 25, or 247 ppm triethylamine (TEA) vapor, 6 hr per day, 5 days per week for up to 28 weeks in order to characterize the subchronic organ system toxicity. Rats were weighed biweekly and scheduled sacrifices were performed following about 30, 60, and 120 days of exposure. No statistically significant treatment-related effects on organ weights, hematology, clinical chemistry, or electrocardiographic indices were observed. Body weight gain was not affected by TEA treatment. No physiologic or pathologic evidence of cardiotoxicity was seen in rats exposed to either TEA concencentrations for up to 28 weeks. No gross or histopathological lesions attributable to TEA exposure were noted in any of the organs examined, including the nasal passages.Based on the study results 25 ppm (corresponds to 103.3 mg/m³) is considered to be a NOAEC forTriethylamin . Hence the substance can not be classified as toxicant.
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