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EC number: 212-742-4
CAS number: 865-49-6
Table 1: Mortality occurring in the inhalation toxicity study. Numbers
in brackets indicate the number of rats dying on specified days.
The inhalation toxicity of chloroform vapours to female and male Fisher
344/DuCrj rats was tested over a period of two weeks with exposures for
6 hours per day on five days per week. No mortality occurred at exposure
levels of 500 or 1000 ppm, whereas all test animals died within 48 hours
at exposure levels of 2000 ppm and above. Surviving males and females
exposed to 500 and 1000 ppm had vacuolic changes in proximal tubules of
the kidneys and in the central area of the liver, in addition to
desquamation, atrophy and disarrangement of the olfactory epithelium and
oedema of the lamina propria of the nasal cavity.
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