Registration Dossier
Registration Dossier
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EC number: 606-460-4 | CAS number: 201855-65-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Referenceopen allclose all
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (-)-3R,4R-1-Benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-piperide-L-dibenzoyl tartrate
- EC Number:
- 606-460-4
- Cas Number:
- 201855-65-4
- Molecular formula:
- C19H22FNO + C18H14O8 = C37H36FNO9
- IUPAC Name:
- (-)-3R,4R-1-Benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-piperide-L-dibenzoyl tartrate
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
- Remarks:
- QSAR prediction
Any other information on results incl. tables
| Software | Method | Alert | Predicted value |
| ChemProp | Skin irritation and corrosion | No Structural Alerts were found. | Save |
| Toxtree | Skin irritation / skin corrosion | No Structural Alerts were found. | Not Corrosive to skin |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to (Q)SAR modells: Toxtree, ChemProp, the predicted values indicated that cis-HPD-tartarate is sensitiser. The result meets the requirement of No Hazard Category.
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