Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-291-1 | CAS number: 7011-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-11-24 and 2011-03-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 92/69 EEC, C.4-D, Manometric Respirometry Test, 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: wastewater treatment plant (ARA Ergolz II, Füllinsdorf, Switzerland)
- Preparation of inoculum for exposure: The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated.
- Concentration of sludge (final): 30 mg dry material per liter - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 261 mg/L
- Based on:
- ThOD
- Initial conc.:
- 262 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium accroding to OECD guideline
- Additional substrate: none
- Test temperature: 22°C
- pH: 7.4
- pH adjusted: yes, with a diluted hydrochloric acid solution
- Aeration of dilution water: no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 500 mL reaction vessels
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: The flask were incubated under continuous stirring in a SAPROMAT D12.
- Measurement equipment: electro-chemical analysis process: The generated CO2 is absorbed by soda lime, resulting in a decrease of the total pressure in the airtight flasks. The pressure drop is detected and converted into an electrical signal by means of an electrode type manometer.
- Test performed in open system: Yes
SAMPLING
- Sampling frequency: daily on each working daily
CONTROL AND BLANK SYSTEM
- Inoculum blank: mineral medium containing only inoculum
- Toxicity control: mineral medium containing test substance, reference substance and inoculum - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- Not performed
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 82
- Sampling time:
- 28 d
- Remarks on result:
- other: 10-day window passed
- Details on results:
- At the end of the 28-day exposure period, the mean biodegradation of the test item amounted to 82%. The pass level for ready biodegradability, i.e. biodegradation of at least 60% of the ThOD in a 10-day window within the 28-day period of the test, was reached. In the toxicity control, biodegradation amounted to 42% within 14 days of exposure. Thus, the test item had no inhibitory effect on activated sludge microorganisms at the tested concentration of 100 mg/L. Please refer to 'any other information on results' for more details.
- Results with reference substance:
- The reference item sodium benzoate was degraded by an average of 90% by exposure day 14, and reached an average biodegradation of 96% by the end of the test (Day 28).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- At the end of the 28-day exposure period, the mean biodegradation of the test item amounted to 82%.
- Executive summary:
The test item was investigated for its ready biodegradability in a manometric respirometry test over 28 days according to OECD TG 301 F, Commission Directive 92/69 EEC, C.4 -D and Commission Regulation (EC) No 440/2008, C.4 -D. The percent of biodegradation of the test item was calculated based on the theoretical oxygen demand (ThOD) of 2.61 mg O2/ mg test item). The biochemical oxygen demand (BOD) of the test item in the test media significantly increased from exposure day 6 until test termination after 28 days. At the end of the 28 -day exposure period, the mean biodegradation of the test item amounted to 82%. Consequently, the test item was found to be biodegradable by 82% under the test conditions within 28 days. Moreover, the pass level for ready biodegradability, i.e. biodegradation of at least 60% of the ThOD in a 10-day window within the 28-day period of the test, was reached. In the toxicity control, containing both test item and the reference item sodium benzoate, the test item had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration of 100 mg/L. In the procedure controls, the reference item sodium benzoate was degraded by an average of 90% by exposure day 14, and reached an average biodegradation of 96% by the end of the test (Day 28), thus confirming suitability of the activated sludge.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to attached "Read-across justification".
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 82
- Sampling time:
- 28 d
- Remarks on result:
- other: 10-day window passed
Referenceopen allclose all
Biodegradation in the test flasks
Time (days) |
Percentage Biodegradation* |
||||
Test item |
Procedure control |
Toxicity control |
|||
Replicate No. |
Replicate No. |
Replicate No. |
|||
1 |
2 |
1 |
2 |
1 |
|
0 |
0 |
0 |
0 |
0 |
0 |
1 |
-1 |
1 |
16 |
13 |
9 |
2 |
0 |
1 |
56 |
56 |
23 |
3 |
0 |
1 |
72 |
71 |
28 |
4 |
0 |
1 |
77 |
75 |
29 |
5 |
0 |
2 |
81 |
79 |
30 |
6 |
5 |
8 |
83 |
81 |
31 |
7 |
16 |
13 |
84 |
82 |
31 |
8 |
27 |
30 |
86 |
83 |
32 |
9 |
- |
- |
- |
- |
- |
10 |
- |
- |
- |
- |
- |
11 |
45 |
51 |
89 |
86 |
35 |
12 |
50 |
57 |
90 |
87 |
37 |
13 |
55 |
60 |
91 |
88 |
39 |
14 |
58 |
63 |
91 |
88 |
42 |
15 |
62 |
67 |
92 |
89 |
47 |
16 |
66 |
72 |
94 |
90 |
51 |
17 |
68 |
75 |
94 |
91 |
53 |
18 |
70 |
77 |
94 |
91 |
55 |
19 |
72 |
79 |
95 |
92 |
58 |
20 |
73 |
81 |
96 |
92 |
60 |
21 |
75 |
82 |
96 |
92 |
62 |
22 |
76 |
82 |
97 |
92 |
65 |
23 |
- |
- |
- |
- |
- |
24 |
- |
- |
- |
- |
- |
25 |
78 |
84 |
97 |
93 |
69 |
26 |
79 |
84 |
98 |
93 |
70 |
27 |
79 |
84 |
98 |
93 |
71 |
28 |
80 |
84 |
98 |
93 |
73 |
Mean (day 28) |
82 |
96 |
Not applicable |
* Corrected for the mean oxygen uptake of the inoculum controls
- not determined
Description of key information
Based on an read-across approach, the test substance is considered to be readily biodegradable according to OECD criteria.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
For the test substance no biodegradation tests are available.
Therefore, an analogy approach to the read-across substance Reaction mass of trans-5 -hexyldihydro-4 -methylfuran-2(3H)-one and cis-5 -hexyldihydro-4 -methylfuran-2(3H)-one is applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.