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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1956
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older publication: Some experimental details are missing, but basic data given

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene. Experiments on laboratory animals
Author:
Wolf MA, Rowe VK, McCollister DD, Hollingsworth RL & Oyen F
Year:
1956
Bibliographic source:
AMA Arch Ind Health 14, 387 - 398

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
respiratory irritation
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Calculated amounts of the TS were introduced into the atmosphere of an enclosed, tightly sealed room. Utilising sensitive analytical procedures, the concentration within the room was determined. Then the subjects (no further information available) entered the room quickly and noted their reactions with respect to odour, eye irritation, and nasal irritation
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylpropene
EC Number:
202-705-0
EC Name:
2-phenylpropene
Cas Number:
98-83-9
Molecular formula:
C9H10
IUPAC Name:
(prop-1-en-2-yl)benzene
Details on test material:
Name of test material (as cited in study report): alpha-Methyl styrene
Purity: 98.6 - 99.1 % (obtained by UV or IR analysis)
Boiling point: 165.4 degrees C
Specific gravity: 0.91 (at 20 degrees C)

Method

Type of population:
not specified
Subjects:
no further information available
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
Exposure from <= 10 to >= 600 ppm

Results and discussion

Clinical signs:
Response of the subjects:
< 10 ppm: odour not detectable
50 ppm: odour detectable, no mucous membrane irritation
100 ppm: strong tolerable odour
200 ppm: strong objectionable odour
>= 600 ppm: very strong odour, strong eye and nasal irritation
Results of examinations:
In this study with limited documentation, human volunteers were exposed to concentrations of <= 10 to >= 600 ppm. At the highest concentration of >= 600 ppm, the exposure caused strong eye and nasal irritation.

Applicant's summary and conclusion

Conclusions:
In this study with limited documentation, the exposure of human subjects to concentrations of >= 600 ppm caused strong eye and nasal irritation.
Executive summary:

In this study with limited documentation, human volunteers were exposed to concentrations of <= 10 to >= 600 ppm. At the highest concentration of >= 600 ppm, the exposure caused strong eye and nasal irritation.