Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, however, limited documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Selective degeneration in the rat olfactory bulb following exposure to different odours
- Author:
- Pinching AJ, Doving KB
- Year:
- 1 974
- Bibliographic source:
- Brain Research 82: 195-204
Materials and methods
- Principles of method if other than guideline:
- Animals were exposed to constant nitrobenzene vapour. The animals were sacrificed at about 1, 2 and 3 months of age. As to control, animals exposed to filtered fresh air only.
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Nitrobenzene
- Molecular formula (if other than submission substance): C6H5NO2
- Molecular weight (if other than submission substance): 123
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 2 weks
- Weight at study initiation: 28 - 39 g
- Fasting period before study: no dat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: room air filtered through filters of charcoal and molecular sieves
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 or 10 weeks
Sacrifice after 5 and 10 weeks, respectively - Frequency of treatment:
- continuously constant
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5.4E-111M
Basis:
other: Difference of the weight between before and after the experiment.
- No. of animals per sex per dose:
- 4 totally, no data about the sexuality of animals tested
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
Microscopic examination of the olfactory bulb revealed a degeneration of the mitral cell layer, representing the principal relay neurones, with the most densely degeneration in the ventral region.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
