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EC number: 237-159-2
CAS number: 13674-87-8
Several long-term studies with the zebrafish Danio rerio have
been performed, using TDCP as as test substance. None of these tests
followed a standard guideline that is typically used for the log-term
assessment of a chemical for fish. Wang et al (2015), however, conducted
a 6 month experiment using freshly fertilized eggs as starting material
and exposing these organisms continuously to TDCP for a six month
period. This timeframe is longer than typical exposure periods that are
provided in standard long term guidance documents. The lifestages that
were tested cover the most sensitive phases of development. Finally, the
evaluated endpoint “weight” is relevant for environmental assessment
A 6-month ECx of 4 µg/L was determined for D.rerio, with x
situated between 10 and 20%. The ECHA Guidance Document on information
requirements and chemical safety assessment (Chapter R.10:
Characterisation of dose (concentration)-response for environment) does
provide guidance on how to deal with studies that report ECx levels
deviating from the classical 10%. More specifically, Table R.10-1
“Overview of toxicity test endpoints and guidance on derivation of L(E)C50
and NOEC values” : LOEC >10 and <20% effect: NOEC can be calculated as
According to this methodology, a NOEC of 2 µg/L can be estimated for D.
rerio (NOEC = LOEC:2 = ECx% : 2 = 4:2 µg/L = 2 µg/L)
All other studies resulted in NOEC-values that ranged from 4 to 300
µg/L; these studies covered shorter exposure periods, and both testing
procedures as well as endpoints sometimes significantly deviated from
conventional protocols that are typically used when assessing long-term
effects to fish. None of the other studies with D.rerio generated
a NOEC that was lower than the value derived from Wang et al (2015).
It should also be noted that the value of 2 µg/L is a factor of 500
lower than the NOEC value of 1 mg/L that was determined using a QSAR.
No long-term data for marine fish were identified.
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