Registration Dossier
Registration Dossier
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EC number: 242-555-3 | CAS number: 18755-43-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to DRAIZE.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl propylphosphonate
- EC Number:
- 242-555-3
- EC Name:
- Dimethyl propylphosphonate
- Cas Number:
- 18755-43-6
- Molecular formula:
- C5H13O3P
- IUPAC Name:
- dimethyl propylphosphonate
- Test material form:
- other: clear colourless liquid
- Details on test material:
- - Purity: 98.7 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 3 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1.55
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 h
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Other effects:
- no other effects
Any other information on results incl. tables
Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).
Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.
Applicant's summary and conclusion
- Executive summary:
A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to Draize.
Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).
Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.
The findings indicates that dimethyl propylphosphonate may be considered as slight irritating to the eyes. According GHS a classification as Eye Irrit. 2; H 319 is appropritate due to a cornea score = 1.
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