Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study, that meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- 5 mice per sex per dose were intraperitoneally administered the test substance. The animals were observed for mortality and clinical signs during 14 days. At the end of the study necropsy was performed on the surviving animals.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-diazabicyclooctane
- EC Number:
- 205-999-9
- EC Name:
- 1,4-diazabicyclooctane
- Cas Number:
- 280-57-9
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 1,4-diazabicyclooctane
- Details on test material:
- - Name of test material (as cited in study report): Triaethylendiamin, rein - Physical state: solid - Analytical purity: > 98%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kisslegg
- Mean weight at study initiation: 28 g (males); 23 g (females)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 200, 250, 320, 400 and 500 mg/kg bw (2% (w/v) in aqueous solution)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 6/10 animals died in the 400 mg/kg bw dose group.
- Mortality:
- - 200 mg/kg bw: 1/10 animals died
- 250 mg/kg bw: 2/10 animals died
- 320 mg/kg bw: 1/10 animals died
- 400 mg/kg bw: 6/10 animals died
- 500 mg/kg bw: 10/10 animals died
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
